On Campus

Attacking a tumor's longevity via telomerase

Telomerase, the protein that keeps cells alive by adding new bits of DNA to chromosomes, may be a target for treatment against cancer, according to David R. Corey, Ph.D., an associate professor of pharmacology and biochemistry at the University of Texas Southwestern Medical Center in Dallas. At Cancer Center grand rounds in March, Corey suggested that oligonucleotides could inhibit telomerase, which is found in 80 percent of solid tumors.

Although its normal job is to repair telomeres, which maintain chromosomes, telomerase confers a kind of immortality on tumors. Corey found that certain oligonucleotides, small clusters of nucleic acids, caused tumor cells to grow more slowly and eventually die. When the oligonucleotides were withdrawn, the tumor cell grew at a normal rate.

“You would not ever think about giving a telomerase inhibitor as a primary treatment to try to shrink the tumor,”...

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Smallpox an unlikely threat, syas Horstmann lecturer

When smallpox reached the New World, it quickly decimated the indigenous population, said John M. Neff, M.D., professor of pediatrics at the University of Washington and the Children’s Hospital in Seattle. A similar, devastating outbreak is unlikely today, Neff told an audience in April for the Dorothy Horstmann Lecture at pediatric grand rounds.With the disease eradicated since the 1970s, Neff said, the threat...

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From the right, a different take on bias in medicine

From the right, a different take on bias in medicine

The same day that Sally Satel, HS ’88, spoke on political correctness at the medical school, an Institute of Medicine...

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Technology as a weapon against suffering

During his 28 years as a biomedical engineer, Robert S. Langer, Sc.D., has received four honorary doctorates, published...

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Linking HIV care to socioeconomics

Many interventions aimed at stemming the spread of AIDS miss the point, says Tom Peterman, M.D., chief of the...

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