Michael Harris Nathanson MD, PhD

Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology; Section Chief, Digestive Diseases; Director, Yale Liver Center; Director, Center for Cell and Molecular Imaging

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Yale Medical Group

Office of Student ResearchTransplantation Center, Yale-New HavenCell Biology: Membrane Traffic; Center for Cellular and Molecular ImagingInternal Medicine: Digestive Diseases: Hepatology; Gastrointestinal Procedure Center

Research Interests

Mechanisms and effects of calcium signals in polarized epithelia; Effect of spatial organization of calcium signals on organ function regulation; Factors that organize Ca2+ waves in hepatocytes; Organization and effects of Ca2+ waves in cholangiocytes; Mechanisms and effects of Ca2+ signals in the nucleus

Clinical Interests

Inpatient care related to hepatology; end stage liver disease, and gastroenterology; Advanced endoscopic imaging techniques; endomicroscopy.


  • B.S., University of California, Berkeley , 1976
  • M.S., Massachusetts Institute of Technology , 1977
  • Ph.D., Case Western Reserve Univ , 1983
  • M.D., Case Western Reserve Univ , 1985

Selected Publication

  • Mennone, A., and Nathanson, M.H.: Needle-based confocal laser endomicroscopy to assess liver histology in vivo. Gastrointestinal Endoscopy, in press.

Latest Honor and Recognition

  • FAPESP Fullbright Scholar(2007)
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