Frederick J. Sigworth PhD

Professor of Cellular and Molecular Physiology and of Biomedical Engineering

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Medicine, Pharmacology, and Physiology | Biochemistry, Biophysics and Structural Biology

Office of Student Research

School of Engineering and Applied ScienceHigh Performance ComputationInterdepartmental Neuroscience ProgramCellular & Molecular Physiology: Membrane Proteins - Ion Channels; Membrane Biophysics; Membrane Protein Structure; Graduate Program in Cellular and Molecular Physiology


Fred Sigworth studied applied physics at Caltech and was a graduate student at Yale, working in the laboratory of Charles F. Stevens. He received the PhD in physiology from Yale in 1979. He was a postdoc in the laboratory of Erwin Neher in Göttingen. He has been a faculty member at Yale since 1984. " How do I see the scientific enterprise? An old book puts it this way: one generation commends God's works to another. It is a great privilege to unravel the workings of ion channels, and to pass on the excitement about these molecular machines to students, colleagues and anyone else who will listen!"


  • Ph.D., Yale University , 1979

Selected Publication

  • Wang L and Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature, 461(7261):292-5, 2009.

Latest Honor and Recognition

  • Alexander von Humboldt Fellow(1979)
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