Graeme F Mason PhD

Professor of Diagnostic Radiology and of Psychiatry; Director Metabolic Modeling and Director Psychiatric MRS; Director, Neuroimaging Sciences Training Program; Chair, Magnetic Resonance Research Center Protocol Review Committee

Departments & Organizations

Office of Student ResearchDiagnostic Radiology: Bioimaging Sciences: Magnetic Resonance Research Center, Magnetic Resonance Spectroscopy; Quantitative Neuroscience with Magnetic Resonance; Neuroimaging Sciences Training Program | Diabetes Research Center | Psychiatry: Center for Nicotine and Tobacco Use Research at Yale (CENTURY); Obsessive Compulsive Disorder Research Clinic; Adult Psychiatry


Dr. Grame F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) in conjunction with 13C isotopic labeling in vivo. His work began during his graduate studies at Yale where he used a rat model for the experimental determination of brain glucose transport kinetics and substrate competition for oxidative brain metabolism. Dr. Mason received further training at the University of Alabama at Birmingham, where he guided the group's 13C-labeling studies of the human brain in vivo in the 4.1T whole-body MR system. Dr. Mason currently studies metabolism and neurotransmission in the brain in vivo, including effects of psychiatric disorders and substances such as alcohol and nicotine; Dr. Mason examines healthy subjects and patients to investigate relationships among GABA, glutamate, and glutamine concentrations and their rates of synthesis and release in the brain, in particular with regard to effects of alcohol and nicotine in acute and chronic use.


  • B.S., The Pennsylvania State University , 1986
  • Ph.D., Yale University , 1991

Selected Publication

  • Wang J, Du H, Jiang L, Ma X, de Graaf R, Behar K, Mason GF (2013) Oxidation and Effects of Ethanol in the Rat Brain after Chronic Ethanol Exposure. Proc Natl Acad Sci USA 110: 14444-14449

Latest Honor and Recognition

  • NIH Graduate Fellowship(1986-1991) , National Institutes of Health
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