Alessandro D. Santin MD

Professor of Obstetrics, Gynecology, and Reproductive Sciences; Clinical Research Program Leader, Gynecologic Oncology Program, Yale Cancer Center

Departments & Organizations

Yale Medical GroupCancer Center, Yale: Gynecologic Oncology Program; Molecular VirologyObstetrics, Gynecology & Reproductive Sciences: Gynecologic Oncology; Ovarian Cancer Program, Early Detection; Cancer Biology Group; Women's Reproductive Health Research Career Development Center; Reproductive Sciences: Discovery to Cure Internship; Discovery to Cure

Research Interests

Mutational landscape of gynecolocic tumors; Therapeutic vaccine development for gynecologic malignancies; Tumor immunology; Immunotherapy; Tumor angiogenesis; Radiation biology; Experimental therapeutics in gynecologic oncology

Clinical Interests

Cancer of the ovary, uterus, vagina, cervix and vulva; Intraperitoneal chemotherapy; Tumor immunology and immunotherapy; Tumor angiogenesis; Radiation biology; Experimental therapeutics in Gynecologic Oncology


  • M.D., University of Brescia School of Medicine , 1989

Selected Publication

  • Bellone S. Roque D. Cocco E. Gasparrini S. Bortolomai I. Buza N. Abu-Khalaf M. Silasi DA. Ratner E. Azodi M. Schwartz PE. Rutherford TJ. Pecorelli S. Santin AD. Downregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy. British Journal of Cancer. 106(9):1543-50, 2012

Latest Honor and Recognition

  • Genetics Institute Young Investigator Award.(1999) , American Association of Cancer Research (AACR)
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