Erol Fikrig MD

Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Investigator, Howard Hughes Medical Institute; Section Chief, Infectious Diseases


Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology | Microbiology

HTI

Microbial Pathogenesis

School of Public Health: Parasitology Program

Skin Diseases Research Center, Yale

Internal Medicine: Infectious Diseases

Molecular Virology

Biography

My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, Human granulocytic ehrlichiosis, and West Nile virus. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Human granulocytic ehrlichiosis is caused by a newly described pathogen, transmitted by Ixodes scapularis ticks, that persists within neutrophils. We are investigating the molecular strategies that this pathogen uses to survive in polymorphonuclear leukocytes. West Nile virus can cause fatal encephalitis, and we seek to understand the pathogenesis of this emerging disease. Finally, we are also developing molecular approaches to prevent ticks from feeding on a mammalian host, thereby interfering with pathogen transmission.

Education

  • BA, Cornell University , 1981
  • M.D., Cornell University , 1985

Selected Publication

  • Silver, A.C., A. Arjona, W.E. Walker, and E. Fikrig. 2012. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity 36:251-261. 3315694
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