Achillion Pharmaceuticals 
Innovative treatments for infectious diseases (achillion.com)
Founder
Yung-Chi Cheng, Ph.D.,Henry Bronson Professor of Pharmacology

Affomix Corporation
Antibody screening technology
Founder
Michael Snyder, Ph.D., former Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and professor of molecular biophysics and chemistry

Alexion Pharmaceuticals
Treatments for rare diseases (alxn.com)
Founders
Leonard Bell, M.D. ’84, former assistant clinical professor of medicine and pathology
Joseph A. Madri, M.D., Ph.D., HS ’76, professor of pathology

Applied Spine Technologies 
Spinal implant device
Founder
Manohar M. Panjabi, Ph.D., professor emeritus of orthopaedics and rehabilitation

Axerion Therapeutics
Treatments for spinal cord injury and Alzheimer disease
Founder
Stephen M. Strittmatter, M.D., Ph.D., Vincent Coates Professor of Neurology and professor of neurobiology

BioRelix
Antibiotic discovery
Founder
Ronald Breaker, Ph.D., Henry Ford II Professor of Molecular, Cellular, and Developmental Biology

Carigent Therapeutics
Drug delivery technology
Founders
W. Mark Saltzman, Ph.D., chair and Goizueta Foundation Professor of Chemical and Biomedical Engineering
Tarek Fahmy, Ph.D., assistant professor of biomedical engineering

CGI Pharmaceuticals
Kinase drug discovery
Founders
David Armistead, Ph.D.
Mark Velleca, M.D., Ph.D., HS ’97, FW ’99, assistant clinical professor of laboratory medicine
Ira Mellman, Ph.D., former Sterling Professor of Cell Biology and Immunology

CoolSpine LLC
Cooling catheter for use in cardiothoracic surgery
Founder
John A. Elefteriades, M.D. ’76, HS ’81, FW ’83, William W.L. Glenn Professor of Surgery

Helix Therapeutics
Genetic repair therapies
Founder
Peter M. Glazer, M.D., Ph.D., Robert E. Hunter Professor of Therapeutic Radiology

HistoRx
Quantitative histopathology testing and diagnostics (historx.com)
Founders
David L. Rimm, M.D., Ph.D., professor of pathology
Robert L. Camp, M.D. ’97, Ph.D., associate research scientist in pathology

JS Genetics
Genetic tests for Turner’s syndrome and dyslexia (jsgenetics.com)
Founders
Jeffrey R. Gruen, M.D., associate professor of pediatrics (neonatology), investigative medicine, and genetics
Allen E. Bale, M.D., professor of genetics
Scott A. Rivkees, M.D., professor of pediatrics (pediatric developmental biology and biophysics)

L2 Diagnostics
Infectious disease diagnostics 
Founders
Erol Fikrig, M.D., Waldemar Von Zedtwitz Professor of Medicine
Joseph E. Craft, M.D., professor of medicine (rheumatology) and immunobiology
Richard A. Flavell, Ph.D., chair and Sterling Professor of Immunobiology

Marinus Pharmaceuticals
Therapeutics for psychiatric disorders (marinuspharma.com)
Founder
Vincent A. Pieribone, Ph.D., associate professor of physiology

MGS Research Inc.
Medical gel dosimetry systems (mgsresearch.com)
Founders
Marek J. Maryanski, Ph.D.
John C. Gore, Ph.D., former professor of psychology
Robert J. Schulz, Ph.D., professor emeritus of therapeutic radiology

MiraDx
Cancer diagnostics
Founders
Frank Slack, Ph.D., associate professor of molecular, cellular, and developmental biology
Joanne B. Weidhaas, M.D., Ph.D., assistant professor of therapeutic radiology

New Haven Pharmaceuticals 
Therapeutics for depression and GI disorders (newhavenpharma.com)
Founders
John H. Krystal, M.D. ’84, HS ’88, Robert L. McNeil, Jr., Professor of Clinical Pharmacology
John P. Geibel, M.D., Ds.C., professor of surgery (gastroenterology) and cellular and molecular physiology
Wajahat Z. Mehal, Ph.D., assistant professor of medicine (digestive diseases)
Gerard Sanacora, M.D., Ph.D., assistant professor of psychiatry
Vladimir Coric, M.D., associate clinical professor of psychiatry

Optherion
Therapeutics and diagnostics for age-related macular degeneration
Founder
Josephine J. Hoh, Ph.D., associate professor of epidemiology and ophthalmology

PGxHealth, a division of Clinical Data
Biomarker discovery and drug development (pgxhealth.com)
Founder
Gualberto Ruaño, M.D. ’97, Ph.D. ’97

PhytoCeutica
Traditional Chinese botanical remedies developed into FDA-approved drugs for cancer (phytoceutica.com)
Founder
Yung-Chi “Tommy” Cheng, Ph.D., Henry Bronson Professor of Pharmacology

Rib-X Pharmaceuticals
Antibiotic drug discovery and development (rib-x.com)
Founders
Thomas A. Steitz, Ph.D., Sterling Professor of Molecular Biophysics and Biochemistry (and co-recipient of the 2009 Nobel Prize in Chemistry)
Peter B. Moore, Ph.D., Sterling Professor of Chemistry and professor of molecular biophysics and biochemistry
William L. Jorgensen, Ph.D., Sterling Professor of Chemistry

SurExam
Ovarian cancer diagnostics for Chinese market
Founder
Gil G. Mor, M.D., M.Sc., Ph.D., associate professor of obstetrics, gynecology, and reproductive services

Vascular Insights LLC
ClariVein catheter for treating varicose veins (vascularinsights.com)
Founders
John P. Marano Jr., Ph.D. ’69
Michael Tal, M.D., associate professor of radiology