Follow-Up

Research in Iran yields clue to heart disease

In 1998 Arya Mani, M.D., HS ’97, FW ’01, assistant professor of medicine (cardiology), returned to his native Iran to embark on a research project that linked modern genomics with his country’s patterns of intermarriage [See “Journey of the Heart,” Yale Medicine, Spring 2004]. Working with Richard P. Lifton, M.D., Ph.D., chair of genetics, Mani sought a genetic component to heart disease. He also believed that genetic mutations would be more prevalent in families where relatives intermarried.Although their initial research focused on patent ductus arteriosis (PDA), in March the journal Science published Mani and Lifton’s research on metabolic disease, also involving coronary and carotid arteries. They...

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