David Adam Spiegel

Professor of Chemistry

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and PhysiologyHIV/AIDS

Developmental Therapeutics

Molecular Virology


David A. Spiegel was born in New York City, and grew up in Teaneck, New Jersey. From a very young age, he was fascinated by the chemistry and biology of small molecules, and at 16 began doing research in a neuroanesthesiology laboratory at the University of Iowa. He went on to attend Harvard University where he conducted research under the guidance of Professor Yoshito Kishi. After graduating from Harvard, David began in Yale University’s M.D./Ph.D. program. There he conducted graduate research in Professor John Wood’s laboratory focusing on developing synthetic approaches toward the phomoidrides. During the course of these studies, he discovered that trialkylborane-water complexes could function as H-atom donors in free radical reactions. Following graduation from Yale, Professor Spiegel moved back to Harvard for postdoctoral studies under the guidance of Professor Stuart L. Schreiber. There he focused on developing an oligomer-based method for small-molecule synthesis to enable the rapid assembly of skeletally diverse small molecules starting from simple monomers. David began as an assistant Professor at Yale in June of 2007. Since that time, he has been fortunate to be named recipient of the Camille and Henry Dreyfus New Faculty Award, the NIH Director’s New Innovator Award, Ellison Foundation New Scholar Award, Bill and Melinda Gates Foundations Grand Challenges Explorations Award and is the recipient of an Alfred P. Sloan Foundation Fellowship.

Selected Publication

  • Spiegel DA. Synthetic Immunology to Engineer Human Immunity. Nature Chemical Biology. 2010; 6; 871-872. Chosen as one of eight recipients of the 2010 Grand Challenges in Chemical Biology Competition.

Latest Honor and Recognition

  • Alfred P. Sloan Foundation Fellowship(2011)
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