Findings

In yeast studies, a mutated DNA reveals location, function of genes

Yale researchers have discerned the functions of a third of the genes in the yeast genome, using a novel method of DNA insertion that can be applied to other organisms. The new tool will allow researchers not only to identify genes, said principal investigator Michael Snyder, Ph.D., but figure out what they do. “That is going to be the next big challenge,” he said. Snyder and his interdisciplinary team followed, using chemical markers, a mutated, bacterially derived strain of DNA as it interacted with yeast genes and proteins. They observed at what point in the yeast’s life cycle genes were expressed, where in the cell proteins were located and what disruptions the mutated DNA caused. Their results were published in the Nov. 25 issue of the journal Nature.

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Mitochondrial voltage and neural connections

Mitochondria are not only the energy packs of each living cell, but also judge and jury, deciding whether cells live or die. Given that power, aberrant mitochondria have long been suspects in degenerative diseases such as Parkinson’s, in which cells die and crucial neural connections are lost. The strength of those connections depends on electrical activity in the mitochondria—the higher the activity, the stronger...

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A role for serotonin in long-term memory

Yale scientists have discovered a new mechanism for strengthening synapses that store long-term memories. Applying the...

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At last, a close-up view of the transcription process

In a discovery that offers insights into fundamental cellular processes, Yale researchers have observed for the first...

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Shedding light on Salmonella’s Trojan Horse

To invade and occupy a cell, Salmonella first deploys a Trojan horse, a protein called SopE that instructs the cell to...

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New role found for B Cells in gastrointestinal disease

A team of Yale researchers has traced a path of cellular development that may lead to gastrointestinal and other...

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