Thomas A Steitz PhD
Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry; Investigator, Howard Hughes Medical Institute

Departments & Organizations
Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology: DNA Dynamics; Drug Design, Discovery and Mechanism; RNA Catalysis and Ribonucleoprotein Machines; Transcriptional RegulationStructural Biology
Global Health Initiative: Infectious Diseases | Tuberculosis
Molecular Biophysics and Biochemistry: Cell Cycle and Transcriptional Regulation | DNA Replication and Repair | RNA Biology | Structural Biology
Biography
Prof. Thomas Steitz received a B.A. degree in chemistry from Lawrence College in Appleton, Wisconsin, and a Ph.D. degree in molecular biology and biochemistry from Harvard, with William Lipscomb. After a postdoctoral year at Harvard, he moved to the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, to work as a Jane Coffin Childs fellow with David Blow. He next joined the Yale faculty, where he has remained, except for sabbatical work with Klaus Weber in Göttingen, Germany; Aaron Klug at Cambridge; John Abelson at the California Institute of Technology; and Thomas Cech and Olke Uhlenbeck at the University of Colorado. He has received the 2009 Nobel Prize in Chemistry, the Pfizer Prize from the American Chemical Society, the Lewis S. Rosenstiel Award for distinguished work in basic medical sciences, the 2001 Newcomb Cleveland Prize from the American Association for the Advancement of Science, the Lawrence University Lucia R. Briggs Distinguished Achievement Award, the 2006 Keio Medical Science Prize, and the 2007 Gairdner International Award. Dr. Steitz is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. He was recently elected a fellow of the American Association for the Advancement of Science.Education
- BA, Lawrence College , 1962
- Ph.D., Harvard University , 1966
Selected Publication
- Bailey, S., Wing, R.A., and Steitz, T.A. (2006). The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell 126:893-904.
Latest Honor and Recognition
- Nobel Prize in Chemistry(2009) , The Royal Swedish Academy of Sciences
Articles

Autumn 2003
In the footsteps of Watson and Crick
When hundreds of scientists gathered in England in April to celebrate the 50th anniversary of the structure of DNA,...

Summer 2005
Antibiotic-resistant ribosomes unmasked
Five years ago, Yale scientists made a splash with the long-sought atomic structure of the large subunit of the...
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Winter 2010
A Nobel for deciphering the ribosome’s subunit
A few minutes before noon on October 7, Thomas A. Steitz, Ph.D., Sterling Professor of Molecular Biophysics and...

Autumn 2007
Ribosome scholar receives Gairdner Prize
Thomas A. Steitz, Ph.D., Sterling Professor of Molecular Biophysics and Biochemistry, professor of chemistry and a...

Autumn 2011
Nobel laureate named to Royal Society
Thomas Steitz, Ph.D., Sterling Professor of Molecular Biophysics and Biochemistry, and a winner of the Nobel Prize for...

Spring 2008
Six faculty honored as AAAS fellows
Six faculty members in the biomedical sciences were honored as fellows of the American Association for the Advancement...
Spring 2001
Thomas Steitz honored with Sterling Professorship
Thomas A. Steitz, Ph.D., internationally known for his work in X-ray crystallography, has been honored with an...

Spring 2010
Ruslan Medzhitov, Ph.D.
Ruslan Medzhitov, Ph.D., the David W. Wallace Professor of Immunobiology and a Howard Hughes Medical Institute...
Autumn 2003
Jorge E. Galán, Ph.D., D.V.M., Thomas A. Steitz, Ph.D.
Jorge E. Galán, Ph.D., D.V.M., chair and Lucille P. Markey Professor of Microbial Pathogenesis and professor of cell...

Autumn 2003
Jorge E. Galán, Ph.D., D.V.M., Thomas A. Steitz, Ph.D.
Jorge E. Galán, Ph.D., D.V.M., chair and Lucille P. Markey Professor of Microbial Pathogenesis and professor of cell...

Spring 2007
Thomas A. Steitz, Ph.D.
Thomas A. Steitz, Ph.D., Sterling Professor of Molecular Biophysics and Biochemistry, received the 11th Keio Medical...

Spring 2010
Biotech after the bust
After the U.S. and world economies faltered in the fall of 2008, it became clear that future plans for Yale’s various...

Autumn 2008
Is the straight road too narrow?
Demands for cures and a flat NIH budget are putting pressure on scientists to produce findings that go right to the...
Fall 2000 | Winter 2001
Yale researchers solve structure of the ribosome
In a landmark achievement, Yale researchers have determined the atomic structure of the ribosome’s large subunit,...
Fall 1999 | Winter 2000
In the ribosome, clues to better antibiotics
Yale scientists have produced three-dimensional images of the largest component of the ribosome — the cellular...



