Joan A Steitz PhD

Sterling Professor of Molecular Biophysics and Biochemistry; Investigator, Howard Hughes Medical Institute

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Departments & Organizations

Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology: RNA Catalysis and Ribonucleoprotein Machines

Stem Cell Center, Yale: Transcriptional Regulation of Stem and Progenitor Cells

Molecular Virology

Center for RNA Science and Medicine, Yale

Molecular Biophysics and Biochemistry: RNA Biology

Molecular Virology

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Biography

As a college student in the 1960s, Joan Steitz never imagined herself as a top-flight scientist. Certainly, she was fascinated by science. She even assisted senior scientists in laboratories at the Massachusetts Institute of Technology, where she was befriended by James D. Watson, co-discoverer of the DNA double helix, and at the Max Planck Institute in Germany. But when it came time to choose a career path, Steitz had convinced herself that she was not devoted enough to research to spend grueling nights and weekends in the laboratory.

Today, Prof. Joan Steitz is one of leading scientists in her field. Steitz is best known for her pioneering work in RNA. She discovered and defined the function of small ribonucleoproteins (snRNPs) in pre-messenger RNA—the earliest product of DNA transcription—and was the first to learn that these cellular complexes (snRNPs) play a key role in processing messenger RNA by excising noncoding regions and splicing together the resulting segments. Her breakthroughs into the previously mysterious splicing process have clarified the science behind the formation of proteins and other biological processes, including the intricate changes that occur as the immune system and brain develop. Steitz earned her Ph.D. from Harvard in 1967. After completing postdoctoral work in Cambridge, England, she joined the Department of Molecular Biophysics and Biochemistry at Yale as an assistant professor and later became an associate and full professor, as well as chair of the department.