Charles J Lockwood MD, MHCM
Professor (Adjunct) of Obstetrics, Gynecology, and Reproductive Sciences
Departments & OrganizationsYale Medical GroupObstetrics, Gynecology & Reproductive Sciences
Charles J. Lockwood, M.D., M.H.C.M. is presently Dean at the University of South Florida, Tampa - Morsani College of Medicine, and Senior Vice President of USF Health. He has also been Dean and Vice President for Health Sciences at The Ohio State University College of Medicine since departing Yale. He is the former Anita O’Keeffe Young Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine. Dr. Lockwood received his undergraduate education at Brown University majoring in developmental biology and graduating magna cum laude. His MD was earned from the University of Pennsylvania where he was president of his graduating class. His Masters in Healthcare Management is from Harvard.
He served a residency in Obstetrics & Gynecology at Pennsylvania Hospital, a fellowship in Maternal-Fetal Medicine at the Yale-New Haven Hospital, and postdoctoral fellowship in coagulation in the laboratory of Dr. Yale Nemerson at the Mount Sinai Medical Center. Dr. Lockwood served as Director of Perinatal Research at Mount Sinai Medical Center in New York, and prior to joining the Yale Faculty was Chair of Ob/Gyn at New York University. He is a member of the Institute of Medicine and of the Sigma Xi and Alpha Omega Alpha honor societies, has over 270 peer-reviewed publications, has edited four text books, and is the section editor for obstetrics of UpToDate OB/Gyn.
He serves on multiple editorial boards and is the Editor-in-Chief of Contemporary OB/Gyn. He is the past Chair of the American College of Obstetricians and Gynecologists’ (ACOG) Committee on Obstetrical Practice and ACOG’s Document review Committee (obstetrics). He has served as the Secretary-Treasurer and President of the Society for Gynecologic Investigation (SGI). He has garnered multiple grants from the National Institutes of Health (NIH), March of Dimes and private foundations. Dr. Lockwood’s primary clinical interests include the prevention of recurrent pregnancy loss, preterm delivery, and maternal thrombophilias, and he has been credited with helping to develop fetal fibronectin, the first biochemical predictor of prematurity.
His March of Dimes funded translational research focuses on mechanisms of reduced progesterone receptor expression and/or activity in decidual cells in the setting of preterm labor due to abruption, chorioamnionitis and stress. His lab also studies endometrial and decidual hemostasis and related bleeding disorders. Much of the work has focused on tissue factor expression in normal and disease states. Because tissue factor has been shown not only to be a hemostatic factor, but a critical angiogenic factor as well, his laboratory has studied expression of this molecule in highly angiogenic diseases such as endometriosis. He has demonstrated that tissue factor is highly expressed in ectopic endometriotic lesions and that these lesions can be eradicated with a novel immunoconjugate molecule targeting tissue factor. This research has implications for bench-side to bedside applications. Dr. Lockwood has been cited on the “Best Doctors” lists by American Health Magazine, and Castle Connolly’s survey for the past 16 years.