Findings

Insulin recognized as target in diabetes

Cells that cause diabetes do so by launching aggressive attacks on insulin proteins, Yale researchers have found. This finding could lead to strategies for diverting these attacks and thwarting the disease.

Published in the September issue of Nature Medicine, the study is the first to identify the autoantigen recognized by diabetes-causing CD8 T cells (T lymphocytes) in the Non-Obese Diabetic Mouse, one of the best animal models for research of human diabetes.

These findings should make it easier to discover the genetic and environmental influences that allow autoreactive clones — cells that react to the body’s own proteins — to emerge and thrive in people with diabetes, according to F. Susan Wong, M.D., Ph.D., an associate research scientist in the Section of Immunobiology.

“This is the first time that the target of CD8 cells that cause Type 1 diabetes has been recognized,” said Wong, one...

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Mental health cuts found costly

A reduction in mental health services at a large Connecticut corporation triggered an increase in medical-care use and sick leave, costing the company more money rather than less, according to a Yale study.“This is the first study to show that there exists a point where reducing mental health dollars can be bad for both employees and employers,” said Robert Rosenheck, M.D., HS ’77, professor of psychiatry and public...

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Telomerase and the fight against cancer

Telomerase, an enzyme that makes cancer cells grow, is a better target for chemotherapy than previously thought, a Yale...

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Child care and school readiness

A six-year study at Yale and three other institutions has reached what appears to be a fairly obvious conclusion:...

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Better odds with angioplasty

Balloon angioplasty offered better odds of survival over clot-dissolving drugs for elderly heart-attack patients,...

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