Gerald S Shadel PhD

Professor of Pathology and of Genetics; Director, Pathology Research

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Cancer Genetics & Genomics

Integrative Cell Signaling & Neurobiology of Metabolism (ICSNM)

Pathology: Shadel Lab | ExPath



Gerald S. Shadel received a B.S. from the University of Nevada, Las Vegas in 1986 and his Ph.D. from Texas A&M University in 1991. He went on to Stanford University, where he was a Damon-Runyon postdoctoral fellow and studied the mechanism of mitochondrial gene expression. As an Assistant/Associate Professor of Biochemistry at Emory University from 1997-2004, he continued research in this area using biochemical methods and yeast and tissue culture models. He is currently a Professor of Pathology and Genetics at Yale University, where he studies the role of mitochondria in human disease and aging, now also using mouse models. In 2007, Dr. Shadel received the Amgen Outstanding Investigator Award from ASIP recognizing his contributions in this important area of research and medicine.


  • B.S., University of Nevada, Las Vegas , 1986
  • Ph.D., Texas A & M University , 1991

Selected Publication

  • West AP, Tal MC, Staron M, Pineda CM, Lang SM, Bestwick M, Raimundo N, Khoury-Hanold W, MacDuff DA, Duguay BA, Smiley JR, Kaech SM, Means RE, Iwasaki A & Shadel GS. (2015) Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response. Nature

Latest Honor and Recognition

  • Amgen Outstanding Investigator Award(2007) , American Society for Investigative Pathology