Michael Simons MD, FACC, FAHA

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology


Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Vascular Biology and Therapeutics Program

Animal Organogenesis

Cell Biology: Developmental Cell Biology and Genetics

Internal Medicine: Cardiovascular Medicine: Yale Cardiovascular Clinical Research; Yale Cardiovascular Research Center | Simons Lab

Biography

Dr. Simons is a graduate of Massachusetts Institute of Technology and Yale University School of Medicine. He completed his clinical training in internal medicine at the New England Medical Center in Boston and cardiology training at the Beth Israel Hospital in Boston. He completed a postdoctoral fellowships in molecular cardiology at National Heart Lung and Blood Institute in Bethesda and in vascular biology at MIT. In 1993 he joined faculty at Harvard Medical School as an Assistant Professor of Medicine and rose through the ranks to become an Associate Professor of Medicine, Director of the Morse Coronary Care Unit and Director of Angiogenesis Research Center. In 2001 he was recruited to Dartmouth as AG Huber Professor of Medicine and Chief of Cardiology, subsequently becoming Director of Dartmouth Cardiovascular Center.

Dr. Simons’ research focuses on biology of arterial vasculature and spans basic, translational and clinical areas of investigations. He led the first trials of therapeutic angiogenesis in the USA and his basic research discoveries have played an important role in moving the field forward. Dr. Simons has an extensive track record of NIH funding including multiple R01s and he has served as a Principal Investigator of the NHLBI SCOR program in endothelial biology. Recently, he has been awarded a Leducq Transatlantic network grant to build and lead the ARTEMIS arteriogenesis network composed of investigators in USA, UK, Belgium and France. Dr. Simons also leads an NHLBI PPG program focused on arteriogenessi. He has published over 270 research papers and reviews and has been elected to a number of honorary societies including Association of American Physicians, American Society of Clinical Investigations and Association of University Cardiologists. He also a Fellow of the American Heart Association, American College of Cardiology and the American Society of Physiology.


Education

  • B.S., Massachusetts Institute of Technology , 1980
  • M.D., Yale University , 1984

Selected Publication

  • Elfenbein A, Lanahan AA, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M. Syndecan 4 regulates endothelial FGFR1 signaling by directing macropinocytosis. Science Signaling 2012; 5:ra36. doi: 10.1126/scisignal.2002495 PMID: 22569333

Latest Honor and Recognition

  • Honorary Fellow, University College London(2011) , UCL