Patrick G Gallagher MD
Professor of Pediatrics (Neonatology), of Genetics and of Pathology; Director, Yale Center for Blood Disorders; Director, Expression and Genomics Core, Yale Center of Excellence in Molecular Hematology
Neonatal hematology; Erythropoiesis; Inherited abnormalities of the erythrocyte including metabolic, membrane, and hemoglobin disorders; Sickle cell disease; Hereditary spherocytosis; Elliptocytosis; Pyropoikilocytosis; Stomatocytosis
Dr. Gallagher’s research focuses on the genetic basis of inherited disorders of the erythrocyte and the molecular control of erythropoiesis. Dr. Gallagher’s research is funded by the NIH and private foundations. Current NIH support includes two R01 awards, ARRA supplements, and P30 support for the Yale Center for Excellence in Molecular Hematology (YCEMH). Dr. Gallagher is PI of the Expression and Genomics Core of the YCEMH. He is also supported by an Innovation in Clinical Research Award from the Doris Duke Foundation. Dr. Gallagher is fully engaged in the Yale scientific community, with a joint appointment in Genetics, and active membership in both the Yale Stem Cell Center and the Yale Cancer Center. He is director of the Yale Center for Blood Disorders.
Current extramural activities include Editorial Board service for the Journal of Biological Chemistry, the American Journal of Hematology, Pediatric and Developmental Pathology, BMC Pregnancy and Childbirth (Associate Editor), and Blood Cells, Molecules and Disease and grant and abstract reviewing for numerous NIH, private foundations, and academic society meetings including PAS. He recently finished a two-year-term as chair of the NIH Erythrocyte and Leukocyte Biology Study Section and is currently chair of the American Society of Hematology Scientific Subcommittee on Hemoglobin/Red Cell.
Extensive Research Description
Dr. Gallagher has trained numerous undergraduate, graduate
and medical students, MD and PhD postdoctoral fellows, and sabbatical faculty.
Laboratory graduates hold positions throughout the world and trainees have
received awards and honors from local, regional, and national organizations. In
addition to this T32, he participates in training grants in Genetics, Pathology
and Medicine. He serves on the Department of Pediatrics Scholarship Oversight
Committee (SOC). He has served on numerous individual SOCs as member or chair,
as well as various medical and graduate school mentoring committees, PhD thesis
committees, etc. Directing the Perinatal Medicine fellowship is a vital part of
Dr. Gallagher’s activities as a Yale
- Laflamme K, Owen AN, Devlin EE, Yang MQ, Wong C, Steiner LA, Garrett LJ, Elnitski L, Gallagher PG, Bodine DM.Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter. Mol Cell Biol. 2010 Jul;30(14):3493-502. Epub 2010 May 17. PMID:20479128
- Li D, Harper SL, Tang HY, Maksimova Y, Gallagher PG, Speicher DW.
A comprehensive model of the spectrin divalent tetramer binding region deduced using homology modeling and chemical cross-linking of a mini-spectrin.
J Biol Chem. 2010 Sep 17;285(38):29535-45. Epub 2010 Jul 6.PMID: 20610390
- Yang MQ, Laflamme K, Gotea V, Joiner CH, Seidel NE, Wong C, Petrykowska HM, Lichtenberg J, Lee S, Welch L, Gallagher PG, Bodine DM, Elnitski L. Genome-wide detection of a TFIID localization element from an initial human disease mutation.
Nucleic Acids Res. 2011 Mar;39(6):2175-87. Epub 2010 Nov 11.PMID: 21071415
- Gallagher PG, Steiner LA, Liem RI, Owen AN, Cline AP, Seidel NE, Garrett LJ, Bodine DM. Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis. J Clin Invest. 2010 Dec 1;120(12):4453-65. Epub 2010 Nov 22.PMID: 21099109
- Isern J, He Z, Fraser ST, Nowotschin S, Ferrer-Vaquer A, Moore R, Hadjantonakis AK, Schulz V, Tuck D, Gallagher PG, Baron MH. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood. 2011 May 5;117(18):4924-34. Epub 2011 Jan 24.PMID:21263157
- Hopewell B, Steiner LA, Ehrenkranz RA, Bizzarro MJ, Gallagher PG. Partial exchange transfusion for polycythemia hyperviscosity syndrome. Am J Perinatol. 2011 28(7):557-64. Epub 2011 Mar 1.PMID:21365533
- Massaro SA, Bajaj R, Pashankar FD, Ornstein D, Gallagher PG, Krause DS, Li P.
Pediatr Blood Cancer. Bi-allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia. 2011; 57(3):516-9.Epub 2011 Apr 29. PMID:21538823
- Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S. Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Blood. 2011;118(5):1386-94. Epub 2011 Jun 8. PMID: 21653943
- Bouyer G, Cueff A, Egée S, Kmiecik J, Maksimova Y, Glogowska E, Gallagher PG, Thomas SL. Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum.Blood. 2011 Aug 25;118(8):2305-12. Epub 2011 Jul 27. PMID:21795748
- Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Aug 17. [Epub ahead of print] PMID:21849667