Anna Marie Pyle

William Edward Gilbert Prof of Molecular, Cellular & Developmental Biology; Director, Division of Biological Sciences

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Computational Biology and Bioinformatics | Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Molecular, Cellular, and Developmental BiologyMolecular VirologyStructural BiologyCenter for RNA Science and Medicine, YaleRNA Biology | Structural Biology | Mechanisms of Viral PathogenesisMolecular Virology


Anna Marie Pyle earned her B.A. from Princeton University and her Ph.D. in chemistry from Columbia University. While a graduate student at Columbia, she was awarded the J. Malcolm Miller Teaching Award and the Pegram Award. She conducted her postdoctoral research with Thomas R. Cech at the University of Colorado. Cech and Yale biologist Sidney Altman earned the Nobel Prize for their research showing that certain RNA molecules could catalyze reactions -- a finding that has been a major influence on her work. Prof. Pyle taught at Columbia University for 10 years before joining the Yale faculty in 2002. While at Columbia, she was awarded the Irma T. Hirschl and Monique Weill-Caulier Career Scientist Award and the Searle Scholars Award, and was named a Beckman Young Investigator and a National Science Foundation National Young Investigator. In 2002, she won the New York City Mayor's Award for Excellence in Science and Technology and became a Howard Hughes Medical Institute investigator. At Yale, Prof. Pyle has developed new MB&B courses and has served as director of the Division of Biological Sciences since 2004. She has also served on numerous University committees, including the Curriculum Reform Committee for MB&B, the Biological Sciences Advisory Council and the Graduate Education Committee for MB&B.

Selected Publication

  • Dumont, S., et al. (2006). RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature 439:105-108.