Michael J. Paidas MD

Professor of Obstetrics, Gynecology, and Reproductive Sciences; Vice Chair, Obstetrics; Program Director, Maternal Fetal Medicine Fellowship; Co-Director, Yale Women and Children's Center for Blood Disorders; Co-Director, National Hemophilia Foundation - Baxter Clinical Fellowship Program at Yale; Division of Maternal Fetal Medicine


Departments & Organizations

Obstetrics, Gynecology & Reproductive Sciences: Maternal-Fetal Medicine: Prenatal Diagnostic Service; High-Risk Pregnancy Program; Maternal Special Care Unit; Recurrent Pregnancy Loss Program; Clinicians | Women and Children's Center for Blood Disorders, Yale | Perinatal Research | Endometrial Hemostasis/Thrombosis and Angiogenesis Unit

Prenatal Laboratory

Biography

Michael J. Paidas, M.D. is Professor of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine; Vice Chair, Obstetrics; Program Director, Maternal Fetal Medicine Fellowship; Co-Director of the Yale Women and Children’s Center for Blood Disorders, and Co-Director of the National Hemophilia Foundation-Baxter Clinical Fellowship Program at Yale; Divison of Maternal Fetal Medicine.

Dr. Paidas is the recipient of The David J. Leffell, M.D. Prize for Clinical Excellence at Yale in 2010, given to one member of the Yale Medical Group annually. In 2012, Dr. Paidas received the Dean’s Award from the Tufts Medical Alumni Association. Dr. Paidas is included in the top 1% physician by specialty in the nation according to US News and World Report. He has been recognized by the March of Dimes and is included in Best Doctors in America. Dr. Paidas has also received the National Faculty Award by the Counsel on Resident Education in Obstetrics and Gynecology.

Dr. Paidas received his medical degree from Tufts University School of Medicine in 1987 and completed his internship and residency in Obstetrics and Gynecology in 1991 at Pennsylvania Hospital. In 1993, Dr. Paidas completed a Fellowship in Maternal Fetal Medicine at the Mount Sinai School of Medicine in New York. In 2013, Dr. Paidas was awarded a Master of Arts, Honorary Degree, from Yale University.

Dr. Paidas's career in medicine has focused on women’s health with special emphasis on blood disorders, reproduction, pregnancy complications and the latter’s impact on health and disease. His activities span direct patient care, translational research and clinical trials. Dr. Paidas’s research has been supported by federal and non- federal funding agencies. His notable contributions include: description of the regulatory factors of the Protein C system; clinical use of recombinant antithrombin in disease states; elucidation of the subsequent cardiovascular and non-cardiovascular health consequences of hypertensive disorders and preterm delivery in the largest population based studies published to date.

Dr. Paidas and collaborators have described the genomic and proteomic effects of Preimplantation Factor (PIF), a novel mammalian embryo derived factor which regulates maternal receptivity to pregnancy and possesses key immune modulatory properties. Subsequent animal studies using a synthetic analogue of native PIF have shown benefit in animal models related to a variety of immune diseases, including multiple sclerosis and graft versus host disease.

Dr. Paidas is the lead Prinicipal Investigator of a multicenter preeclampsia treatment clinical trial, entitled Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).

Dr. Paidas has expertise in prenatal ultrasound, invasive fetal diagnostic and therapeutic procedures. His academic profile includes over 500 published manuscripts, abstracts, books, chapters, presentations or courses.


Education

  • B.S., Fairfield University , 1982
  • M.D., Tufts University School of Medicine , 1987
  • M.A., Yale University , 2013

Selected Publication

  • Lykke JA, Langhoff-Roos, Sibai BM, Funai E, Triche EW, Paidas MJ. Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother. Hypertension. 2009 Jun;53(6):944-51.

Latest Honor and Recognition

  • The National Institutes of Health and the Canadian Institutes of Health Research, 5th Annual Summer Institute in Maternal- Fetal Pharmacology, La Sapiniere, Val-David, Quebec, graduate(2009) , NICHD and CIHR