Mark W Hochstrasser PhD

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Office of Student Research

Molecular, Cellular, and Developmental BiologyCancer Center, Yale: Signal TransductionMolecular Biophysics and Biochemistry: Cell Cycle and Transcriptional Regulation; Hochstrasser LabDiabetes Research Center


Part of the Yale faculty since 2000, Prof. Mark Hochstrasser holds appointments in the Department of Molecular Biophysics and Biochemistry, the Department of Molecular, Cellular and Developmental Biology and the School of Medicine’s Biological and Biomedical Sciences Program. He earned his B.A. at Rutgers University and his Ph.D. at the University of California, San Francisco, and conducted postdoctoral research at the Massachusetts Institute of Technology. He has earned numerous honors for his scientific contributions, including a Young Investigator Award from the Cancer Research Foundation and designation as a Searle Scholar and a Fletcher Scholar. Prof. Hochstrasser holds two patents related to this work, which has been published in numerous scientific and medical journals, including Nature, the Journal of Cell Biology, Cell, the Proceedings of the National Academy of Sciences, Genetics and Nature Cell Biology. A member of the editorial board/virtual faculty of the Targeted Proteins Database and the journal Cell, Hochstrasser has served on several National Institutes of Health study sections. He is a member of the American Society for Biochemistry and Molecular Biology, the American Association for the Advancement of Science and the American Society for Microbiology.


  • Ph.D., University of Califoria-San Francisco , 1987

Selected Publication

  • Kusmierczyk, A., Kunjappu, M. J., Funakoshi, M. and Hochstrasser, M. A multimeric assembly factor controls formation of alternative 20S proteasomes. Nature Struct. Mol. Biol. 15, 237-244 (2008)