Ronald Stanton Duman PhD

Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Neurobiology; Director, Abraham Ribicoff Research Facilities

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience

Office of Student ResearchNeuroscience Microarray Center, YaleInterdepartmental Neuroscience ProgramNeurobiologyNIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders | Albert J. Solnit Integrated Training | Psychiatry: Connecticut Mental Health Center; Molecular Psychiatry, Division of; VA-Yale Clinical Neurosciences PTSD Research Program; Stress & Addiction Clinical Research Program; VA National Center for PTSD


Dr. Duman received his doctorate degree from the University of Texas in Houston and conducted postgraduate work at Yale University before joining the faculty there. He has written and/or co-authored over 250 original papers, reviews and book chapters, and has presented over 150 invited lectures. Dr. Duman is also on the editorial board of several prestigious journals and serves as a consultant for a number of biotech and pharmaceutical companies.

Dr. Duman’s work has focused on the molecular and cellular actions of antidepressants and stress, providing the basis for a neurotrophic hypothesis of depression. This hypothesis is based on work demonstrating that chronic antidepressant treatment increases the expression of neurotrophic factors, and increases the proliferation of new neurons and glia in the adult brain. These effects counteract the atrophy and cell loss that is caused by stress and that is thought to underlie, in part, the pathophysiology of depression. These findings represent groundbreaking advances in our understanding of antidepressants and provide a framework for developing novel therapeutic agents.


  • Ph.D., University of Texas , 1984

Selected Publication

  • Kang H-J, B Voleti, T Hajszan, G Rajkowska, C Stockmeier P Licznerski, A Lepack, MS Majik, LS Jeong, M Banasr, H Son, and RS Duman (2012) Decreased expression of synapse related genes and loss of synapses in major depression. Nature Medicine [Epub ahead of print].

Latest Honor and Recognition

  • Anna-Monika Award for outstanding research in depression(2001) , Anna-Monika Foundation