Murat Gunel MD, FACS, FAHA

Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neurobiology; Co-Director, Yale Program on Neurogenetics; Director, Neurovascular Surgery

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Computational Biology and Bioinformatics | Neuroscience | Molecular Cell Biology, Genetics and Development

Yale Medical Group

Office of Student ResearchGamma Knife Center, Yale-New HavenInterdepartmental Neuroscience ProgramCancer Center, Yale: Cancer Genetics & GenomicsVascular Biology and Therapeutics ProgramNeurobiologyGenetics | Neurosurgery: Neurovascular Surgery; Brain Aneurysm & AVM Program; Gamma Knife Radiosurgery; Gunel LabBrain Tumor Research


Dr. Murat Gunel, Professor of Neurosurgery, assumed the position of chief of Neurovascular Surgery Program in January of 2001. Dr. Gunel is a board certified neurosurgeon and is a fellow of the American College of Surgeons. He has special interest in treating brain aneurysms and vascular malformations with special emphasis on arterio-venous malformations and cavernous malformations. He also has expertise in occlusive vascular disorders such as carotid disease and gamma knife surgery (radiosurgery).

His laboratory interests parallel his expertise in clinical neurovascular surgery and focus on gene discovery in disorders of the nervous system and its vasculature. Dr. Gunel's lab completed the two largest genome wide association studies (GWAS) aimed at understanding common variants that underlie intracranial aneurysm genetic risk based on the analysis of over 20,000 subjects. In addition, he is interested in the identification of genes important in human brain development through the study of rare, consanguineous families with recessive forms of malformations of cortical development.


  • M.D., Istanbul University , 1991

Selected Publication

  • Bilgüvar K, Öztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoglu D, Tüysüz B, Çaglayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioglu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MJ, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandas S, Topçu M, Özmen M, Šestan N, Lifton RP, State MW, Günel M: Whole exome sequencing identifies recessive mutations in severe brain malformations, Nature, 467(7312):207-10, 2010.

Latest Honor and Recognition

  • Outstanding Poster Award in Basic Science(2002) , 5th Annual Meeting of the AANS/CNS Section of Cerebrovascular Surgery