Richard Bucala MD, PhD

Professor of Medicine (Rheumatology), of Epidemiology (Microbial Diseases) and of Pathology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology

Yale Medical Group

Office of Student ResearchInfectious DiseasesStem Cell Center, YaleCancer ImmunologyHTI | School of Public Health: Parasitology ProgramSkin Diseases Research Center, Yale | Pathology | Internal Medicine: Rheumatology; Diabetes Research Center

Research Interests

Mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology; Emergence of steroid resistance; Biochemical, biological, and genetic characterization of the MIF cytokine family; MIF's role in malaria and global infectious diseases; Pharmacologic immuniomodulation of the MIF pathway; Role of fibrocytes in different systemic fibroses

Clinical Interests

General Rheumatology; Autoimmune Diseases; Rheumatoid Arthritis; Systemic Fibrosis; Y-NHH Consultation


  • B.S., Yale University , 1979
  • M.S., Yale University , 1979
  • Ph.D., Rockefeller University , 1985
  • M.D., Cornell College , 1986

Selected Publication

  • Sreih A, Ezzeddine R, Leng L, Lachance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel BA, Abelson AK, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, Perl A, Salmon J, Alarcón-Riquelme ME, Harley JB, Bucala R. 2011. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum. 63:3942-3951. PMCID: PMC3228269

Latest Honor and Recognition

  • American Society for Clinical Investigation(1996)