Nancy Hartman Ruddle PhD

Professor Emeritus of and Senior Research Scientist in Epidemiology (Microbial Diseases)


Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology | Microbiology

Stem Cell Center, Yale: Tissue Specific Stem Cells

Cancer Immunology

Vascular Biology and Therapeutics Program

Lymphocyte Development

HTI

School of Public Health: Parasitology Program

Diabetes Endocrinology Research Center

NIH T32 Program

Immunology and Immunotherapy

Biography

Nancy Ruddle is known for her discovery and analysis of lymphotoxin, a protein produced by T cells that plays a role in the protective immune system and destroys tumor cells. She and researchers in her laboratory have engaged in research on the lymphotoxin/tumor necrosis factor family, their regulation and roles in lymphoid organ development and pathogenesis of viral and autoimmune disease. The more than 170 scientific articles Ruddle has authored or co-authored have explored the immunology of such diseases as leukemia, experimental allergic encephalomyelitis and Leishmania amazonensis infection, among others. She continues to generate insight into the regulation and function of lymphoid organs through her analysis of the vessels crucial for their function.


Education

  • Ph.D., Yale University , 1968

Selected Publication

  • Liao, S., Bentley, K., Lebrun, M., Lesslauer, W., Ruddle, F.H, and Ruddle, N.H. (2007). Transgenic lacZ under control of hec-6st regulatory sequences recapitulates endogenous gene expression on high endothelial venules. Proc. Nat. Acad. Sci. (USA) 104:4577-4582.