Alfred L. M. Bothwell PhD

Professor of Immunobiology; Director of Graduate Studies

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology

Program for Biomedical Ethics

Cancer Immunology

Vascular Biology and Therapeutics Program

Immunobiology: HTI

Skin Diseases Research Center, Yale

Diabetes Research Center

Immunology and Immunotherapy

Research Interests

Human T cell recognition; Inflammation and cancer; Type 1 diabetes; Function of PPARs

Clinical Interests

Studies of human T cell recognition of human endothelial cells. The research goals of the Bothwell lab are to characterize the development and function of T cells and to characterize mechanisms that affect T cell recognition and recruitment into vascular sites. In addition, humanized mouse models are being established to study type 1 diabetes and breast cancer.


  • BA, Washington University , 1971
  • Ph.D., Yale University , 1975

Selected Publication

  • Tobiasova, Z., Zhang, L., Yi, T., Qin, L., Kulkarni, S., Rodriguez, F., Choi, J.-M., Tellides, G., Pober, J.S., Kawikova, I. and Bothwell, A.L.M. (2011). PPAR? agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. Circulation 124:196-205.