Alfred L. M. Bothwell PhD

Professor of Immunobiology; Director of Graduate Studies

Departments & Organizations

WHRY Pilot Project Program Investigators

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology

Program for Biomedical Ethics

Office of Student ResearchCancer ImmunologyVascular Biology and Therapeutics ProgramImmunobiology: HTISkin Diseases Research Center, YaleFellowship Training | Diabetes Research CenterImmunology and Immunotherapy

Research Interests

Human T cell recognition; Inflammation and cancer; Type 1 diabetes; Function of PPARs

Clinical Interests

Studies of human T cell recognition of human endothelial cells. The research goals of the Bothwell lab are to characterize the development and function of T cells and to characterize mechanisms that affect T cell recognition and recruitment into vascular sites. In addition, humanized mouse models are being established to study type 1 diabetes and breast cancer.


  • BA, Washington University , 1971
  • Ph.D., Yale University , 1975

Selected Publication

  • Viehmann Milam, A.A., Maher, S.E., Gibson, J.A., Lebastchi, J., Wen, L., Ruddle, N.H., Herold, K.C. and Bothwell, A.L.M. (2014). A Humanized Mouse Model of Autoimmune Insulitis. Diabetes, 63:1712-1724.