Jian Xu PhD

Associate Research Scientist in the Child Study Center

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Departments & Organizations

Child Study Center

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Biography

Education & Training:
Bsc. Genetics, Fudan University, Shanghai, China (2000)
PhD. Genetic Engineering, Fudan University, Shanghai, China (2005)

Research interest: My research focuses on translational work examining the role of STriatal Enriched Protein tyrosine phosphatase (STEP) in neuropsychiatric disorders, including Alzheimer’s disease (AD) and schizophrenia (SZ).

Selected publications:

1. Peer-reviewed articles (from most recent to earliest)

Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ (2012) STriatal-enriched protein tyrosine phosphatase (STEP) regulates Pyk2 activity. J Biol Chem doi:10.1074/jbc.M112.368654 [Epub ahead of print]

Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA (2012) Calpain and Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Activation Contribute to Extrasynaptic NMDA Receptor Localization in a Huntington's Disease Mouse Model. Hum Mol Genet doi: 10.1093/hmg/dds154 [Epub ahead of print]

Sergienko E, Xu J¹, Liu WH, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L (2012) Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation. ACS Chem Biol 7(2):367-377. (¹equal contribution)

Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ (2011) Reduced levels of the tyrosine phosphatase STEP block ß amyloid-mediated GluA1/GluA2 receptor internalization. JOURNAL OF NEUROCHEMISTRY 119(3):664-672.

Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E (2011) Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity. J Neurosci 31(22):8150-8162.

Zhang, YF; Kurup, P; Xu, J; Carty, N; Fernandez, S; Nygaard, HB; Pittenger, C; Greengard, P; Strittmatter, SM; Nairn, AC; Lombroso, PJ (2010) Genetic reduction of STEP tyrosine phosphatase reverses cognitive and cellular deficits in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A 107(44):19014-19019.

Baum, ML; Kurup, P; Xu, J; Lombroso, PJ (2010) A STEP forward in neural function and degeneration. Commun Integr Biol 3(5):419-422.

Kurup, P; Zhang, Y; Venkitaramani, DV; Xu, J; Lombroso, PJ (2010) The Role of STEP in Alzheimer’s Disease. Channels 4(5):347-350.

Kurup, P; Zhang, YF; Xu, J; Venkitaramani, DV; Haroutunian, V; Greengard, P; Nairn, AC; Lombroso, PJ (2010) A beta-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61. J Neurosci 30 (17): 5948-5957.

Xu, J; Kurup, P; Zhang, YF; Goebel-Goody, SM; Wu, PH; Hawasli, AH; Baum, ML; Bibb, JA; Lombroso, PJ (2009) Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP. J Neurosci 29 (29): 9330-9343.

Braithwaite, SP; Xu, J; Leung, J; Urfer, R; Nikolich, K; Oksenberg, D; Lombroso, PJ; Shamloo, M (2008) Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia. Eur J Neurosci 27 (9): 2444-2452.

Chen, JX; Xu, J; Zhao, W; Hu, GH; Cheng, HP; Kang, Y; Xie, Y; Lu, YC (2005) Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Int J Biochem Cell Biol. 37 (11): 2273-2283.

Chen, JX¹; Xu, J¹; Ying, K; Cao, GT; Hu, GH; Wang, L; Luo, C; Lou, MQ; Mao, YJ; Xie, Y; Lu, YC (2004) Molecular cloning and characterization of a novel human BTB domain-containing gene, BTBD10, which is down-regulated in glioma. Gene 340 (1): 61-69. (¹equal contribution)

Chen, JX; Lu, YC; Xu, J; Huang, Y; Cheng, HP; Hu, GH; Luo, C; Lou, MQ; Cao, GT; Xie, Y; Ying, K (2004) Identification and characterization of NBEAL1, a novel human neurobeachin-like 1 protein gene from fetal brain, which is up regulated in glioma. Mol Brain Res 125 (1-2): 147-155.

2. Book Chapters

Xu J, Kurup P, Nairn AC, Lombroso PJ (2012) Striatal Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease. ADVANCES IN PHARMACOLOGY #64-13 (IN PRESS).

Kurup P, Xu J, Goebel-Goody S, Paul S, Lombroso PJ (2013) Striatal-Enriched Protein Tyrosine phosphatase (STEP). S. Choi (ed.), Encyclopedia of Signaling Molecules DOI 10.1007/978-1-4419-0461-4 (IN PRESS).