Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).


Alcohol Dependence | Stress Disorders, Post-Traumatic

What is the purpose of this trial?

Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence.

The objective of this study is to evaluate the efficacy of prazosin (16mg) versus placebo in reducing alcohol consumption and decreasing symptoms of PTSD in patients with comorbid AD and PTSD.

Participation Guidelines

21 Years - 65 Years

Click here for detailed information about who can participate in this trial.

Elizabeth Ralevski
Yale University
January 2009
Last Updated:
January 14, 2014
Study HIC#: ID: NCT00744055