GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
What is the purpose of this trial?
This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence" (balance of positive and negative effects) of the GABAA receptor agonist barbiturate (thiopental) compared to family history negative age-matched subjects. Further, variation in genes involved in brain GABA function may influence the risk for alcoholism by altering a component of the discriminative stimulus effects of ethanol.
- 21 Years - 30 Years
- Yale University
- November 2005
- Last Updated:
- November 2, 2012
- Study HIC#:
Clinicaltrials.gov ID: NCT00611767