GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence

Conditions

Alcoholism

What is the purpose of this trial?

This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence" (balance of positive and negative effects) of the GABAA receptor agonist barbiturate (thiopental) compared to family history negative age-matched subjects. Further, variation in genes involved in brain GABA function may influence the risk for alcoholism by altering a component of the discriminative stimulus effects of ethanol.



Participation Guidelines

Age:
21 Years - 30 Years
Gender:
Both

Click here for detailed information about who can participate in this trial.


Sponsor:
Yale University
Dates:
November 2005
Last Updated:
November 2, 2012
Study HIC#:
0510000664

Clinicaltrials.gov ID: NCT00611767