Arthur A. Simen MD, PhD

Assistant Professor (Adjunct) of Psychiatry

Research Interests

Neurobiology; Neuroscience; Genetics; Epigenetics; Aging; Depression; Stress; Behavioral neuroscience; Statistical methods; Molecular biology; Psychiatry

Current Projects

My lab is engaged in a number of projects and there are ample opportunities for students to get involved with this work. Ongoing projects include work in the areas of basic molecular neuroscience, molecular genetics, behavioral neuroscience, and patient-orientated clinical research.

Research Summary

My lab is committed to helping patients with neuropsychiatric disease through translational research. We are focused on understanding the mechanisms by which genes and stress affect risk for depression, cognitive dysfunction, and other disorders, and how these factors interact with development across the lifespan, from birth to old age. We believe that such research will identify new strategies for treatment and prevention.


Selected Publications

  • Bordner KA, George ED, Carlyle BC, Duque A, Kitchen RR, Lam TT, Colangelo CM, Stone KL, Abbott TB, Mane SM, Nairn AC, Simen AA. Functional genomic and proteomic analysis reveals disruption of myelin related genes and translation in a mouse model of early life neglect. Frontiers in Neurogenomics. 2011. In Press.
  • Bordner KA, Kitchen RR, George ED, Carlyle B, Mahajan MC, Mane SM, Taylor JR, Simen AA (2011). Parallel declines in cognition, motivation, and locomotion in aging mice: association with inflammation in the medial prefrontal cortex. Experimental Gerontology. In Press.
  • Simen AA, Bordner KA, Martin MP, Moy L, Barry LC (2011). Cognitive dysfunction with aging and the role of inflammation. Therapeutic advances in chronic disease. In Press.
  • George ED, Bordner KA, Elwafi HM, Simen AA (2010). Maternal separation with early weaning: a novel mouse model of early life neglect. BMC Neurosci 11: 123.
  • Zhang H, Gelernter J, Gruen JR, Kranzler HR, Herman AI, et al. (2010) Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region. J Hum Genet 55: 278-284.
  • Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, et al. (2010) A negative regulator of MAP kinase causes depressive behavior. Nat Med 16: 1328-1332.

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