Affective Disorders, Psychotic; Affective Symptoms; Behavioral Medicine; Child Development; Family Relations; Genetics, Behavioral; Mental Health; Neuropsychology; Paranoid Personality Disorder; Peer Group; Psychology, Clinical; Psychopathology; Schizoid Personality Disorder; Schizotypal Personality Disorder; Social Adjustment; Social Isolation; Stress, Physiological; Stress, Psychological; Cognitive Therapy; Schizophrenia and Disorders with Psychotic Features; Behavioral Research; Adolescent Development; Resilience, Psychological
Public Health Interests
Behavioral Health; Biomarkers; Data analysis; Epidemiology Methods; Families; Genetics; Human genetic data; Human Subjects Research; Mental Health; Psychiatric Epidemiology; Psychosocial risk factors; Schizophrenia; Statistical genetics; Statistical models; Stress
Extensive Research Description
Dr. Tarbox has a long-standing commitment to research and treatment of schizophrenia and other psychotic disorders. The broad focus of her research is 1) identification of clinical-developmental markers of liability to schizophrenia, 2) examination of the biological/genetic basis of clinical antecedents in relation to schizophrenia epidemiology and pathophysiology, and 3) optimization of risk markers to advance risk prediction and screening, facilitate early detection of illness, and inform evidence-based intervention for young people at risk for schizophrenia.
Dr. Tarbox is especially interested in social functioning and developmental pathology of schizophrenia and the relation between social development, stress sensitivity, and risk/exacerbation of schizophrenia psychosis. Of the many schizophrenia pathologies, poor social functioning is an especially sensitive predictor of familial and non-familial vulnerability, contributes unique information to prediction of psychosis, and appears to be an important correlate of schizophrenia deveopmental pathology. Furthermore, interpersonal skills and social cognition may be key targets for treatment of youth at risk for schizophrenia.
Currently, Dr. Tarbox is conducting a family study to examine genetic correlation of social deficits and psychotic-like symptoms in young people at high-risk for psychosis and their discordant siblings, and in control sibling-pairs. Additional projects include an investigation of the relation between stressful or traumatic experiences in early childhood and contribution to risk for psychosis as well as a collaborative effort to identify genetic polymorphisms associated with onset of psychosis and develop an index of polymorphic risk for psychosis.
- Tarbox, S. I., Addington, J., Cadenhead, K., Cannon, T. D., Cornblatt, B., Perkins, D., Seidman, L.J., Tsuang, M. T., Walker, E., Heinssen, R., McGlashan, T., Woods, S. W. (2014). Functional development in clinical high risk youth: Prediction of schizophrenia versus other psychotic disorders. Psychiatry Research, 215(1), 52-60.
- Tarbox, S. I., Addington, J., Cadenhead, K., Cannon, T. D., Cornblatt, B., Perkins, D., Seidman, L.J., Tsuang, M. T., Walker, E., Heinssen, R., McGlashan, T., Woods, S. W. (2013). Premorbid functional development and conversion to psychosis in clinical high-risk youth. Development and Psychopathology, 25, 1173-1188.
- Tarbox, S. I., Brown, L., Haas, G. L. (2012). Diagnostic specificity of poor premorbid adjustment: Comparison of schizophrenia, schizoaffective disorder, and mood disorder with psychotic features. Schizophrenia Research, 141(1), 91-97.
- Tarbox, S. I., Almasy, L., Gur, R. E., Nimgaonkar, V. L., Pogue-Geile, M. F. (2012). The nature of schizotypy among multigenerational multiplex schizophrenia families. Journal of Abnormal Psychology, 121(2), 396-406.
- Tarbox, S. I., Pogue-Geile, M. F. (2008). Development of social functioning in pre-schizophrenia children and adolescents: A systematic review. Psychological Bulletin, 34, 561-583.