Joel Gelernter, MD

Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience; Director, Division of Human Genetics (Psychiatry)

Research Interests

Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders

Research Summary

The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including cocaine, opioid, nicotine, and alcohol dependence, PTSD, panic and other anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.

The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include NIH-funded multicenter case/control association studies with the goal of identifying genes predisposing to cocaine, opioid, nicotine, and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; an international drug dependence genetics training project in collaboration with Chulalongkorn Faculty of Medicine (Bangkok, Thailand); and studies of posttraumatic stress disorder (PTSD).

Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Gene mapping

Selected Publications

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Contact Info

Joel Gelernter, MD
Mailing Address
Yale Univ. School of Medicine, Dept. PsychiatryVA CT Healthcare Center S116A2
950 Campbell Avenue

West Haven, CT 06516