Adolescent Psychiatry; Bipolar Disorder; Child Psychiatry; Depression; Psychiatry; Mood Disorders; Neuropsychiatry; Endophenotypes
Psychiatry: Neuroscience Research Training Program (NRTP) | Psychotherapy Development Center | Stress & Addiction Clinical Research Program | Women's Behavioral Health Research, Division of | Yale Mood Disorders Research Program
A focus of Dr. Blumberg's laboratory is the use of brain scanning techniques to elucidate the differences in brain circuitry that underlie mood disorders, and how these differences develop. The laboratory has identified differences in parts of the brain that are important in emotional regulation in bipolar disorder, including differences in the pattern of their development in the disorder. For example, the laboratory has identified amygdala differences that are present in adults with bipolar disorder and also in adolescents with bipolar disorder suggesting that these are features that appear early, at least by adolescence in the disorder. Differences in the ventral prefrontal cortex (a part of the brain that includes the orbitofrontal cortex, the part of the prefrontal cortex above the eyes) appear to progress over the course of adolescence in bipolar disorder. This suggests that early intervention might be able to prevent progression and help prognosis. Preliminary evidence suggests treatment may reverse some of the brain differences and may have the potential to prevent this progression.
The lab is working intensively on genetic and environmental factors that may contribute to the differences in development and that may point to new prevention and treatment strategies. Brain scanning techniques used in this work include structural magnetic resonance imaging (MRI) to study the size and shape of brain structures, functional magnetic resonance imaging (fMRI) to study how the parts of the brain function individually and as part of brain circuits, and diffusion tensor imaging (DTI) to study the connections between brain structures.
Specialized Terms: Adolescence; Bipolar Disorder; Brain; Depression; Development; Diffusion Tensor Imaging; Emotion; Endophenotype; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Mania; Manic Depressive Disorder; Neuropsychiatry; Neuroscience; Women
Extensive Research Description
Dr. Blumberg is the Director of The Yale Mood Disorders
Research Program (MDRP). The MDRP is dedicated to understanding the science of mood
disorders, including bipolar disorder (manic-depressive illness) and
depression. The MDRP brings together a multi-disciplinary group of scientists
from across the Yale campus in a highly collaborative research effort. The scientists use a wide variety of scientific
methods to study how genetic and environmental factors affect the brain and
lead to the development of mood disorders. Goals of the MDRP include the
identification of biological markers for mood disorders and discovery of new
treatment strategies. It is hoped that these research efforts will lead to new and
improved methods for early detection and treatment, and someday prevention, of
- MRI Brain Scanning Studies of Adolescents and Adults with Bipolar Disorder
- MRI Brain Scanning Studies of Brain Development in Healthy Adolescents and Adults
- MRI and Gene Studies of Genes and the Brain
- MRI Study of Stress and the Brain in Adolescents and Adults
- Study of Stress, the Brain and the Development of Depression in Adolescents
- Study of Stress, the Brain and the Development of Substance Use Disorders in Adolescents
Olfactocentric paralimbic cortex in adolescent bipolar disorder
Wang F, Kalmar JH, Chepenik LG, Womer F, Pittman B, Gueorguieva R, Blumberg HP. Olfactocentric paralimbic cortex in adolescent bipolar disorder, Brain, 2011, 134:2005-12
Structural and functional connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder.
Wang F, He Y, Jackowski M, Kalmar JH, Chepenik LG, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Structural and functional connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biological Psychiatry 2009, 66: 516-521.
Role of genetic variation in the serotonin transporter in trait disturbances in the ventral anterior cingulate in bipolar disorder.
Shah MP, Wang F, Kalmar JH, Chepenik LG, Tie K, Jones MM, Constable RT, Gelernter J, Blumberg HP. Role of genetic variation in the serotonin transporter in trait disturbances in the ventral anterior cingulate in bipolar disorder. Neuropsychopharmacology 2009, 34:1301-10.
Effects of the brain derived neurotrophic growth factor Val66Met variation on hippocampus morphology in bipolar disorder.
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the brain derived neurotrophic growth factor Val66Met variation on hippocampus morphology in bipolar disorder. Neuropsychopharmacology 2009, 34:944-51
Influence of vascular endothelial growth factor variation on hippocampus morphology.
Blumberg HP, Wang F, Chepenik LG, Kalmar JH, Edmiston E, Duman RS, Gelernter J. Influence of vascular endothelial growth factor variation on hippocampus morphology, Biological Psychiatry 2008, 64:901-903.
Age, rapid-cycling and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study.
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, rapid-cycling and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biological Psychiatry
Amygdala and hippocampus volumes in adolescents and adults with bipolar disorder.
Blumberg HP, Kaufman J, Martin A, Whiteman R, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampus volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry 2003;60:1201-1208
A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices.
Blumberg HP, Leung HC, Skudlarski P, Lacadie C, Fredericks C, Harris B, Charney D, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry 2003;60: 599-607.
Effects of ANK3 variation on gray and white matter in bipolar disorder.
Lippard ET, Jensen KP, Wang F, Johnston JA, Spencer L, Pittman B, Gelernter J, Blumberg HP. Mol Psychiatry. 2016 May 31. doi: 10.1038/mp.2016.76. [Epub ahead of print]
Anterior Cortical Development During Adolescence in Bipolar Disorder.
Najt P, Wang F, Spencer L, Johnston JA, Cox Lippard ET, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Biol Psychiatry. 2016 Feb 15;79(4):303-10. doi: 10.1016/j.biopsych.2015.03.026.
Neurobiological risk factors for suicide: insights from brain imaging.
Cox Lippard ET, Johnston JA, Blumberg HP. Am J Prev Med. 2014 Sep;47(3 Suppl 2):S152-62.
Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder.
de Zwarte SM, Johnston JA, Cox Lippard ET, Blumberg HP. J Clin Med. 2014 Mar 10;3(1):233-54.
Corticolimbic functional connectivity in adolescents with bipolar disorder.
Wang F, Bobrow L, Liu J, Spencer L, Blumberg HP. PLoS One. 2012;7(11):e50177. doi: 10.1371/journal.pone.0050177.
Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system.
Blond BN, Fredericks CA, Blumberg HP. Bipolar Disord. 2012 Jun;14(4):340-55.
Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission.
Kerestes R, Bhagwagar Z, Nathan PJ, Meda SA, Ladouceur CD, Maloney K, Matuskey D, Ruf B, Saricicek A, Wang F, Pearlson GD, Phillips ML, Blumberg HP. Psychiatry Res. 2012 Apr 30;202(1):30-7.
Trait and state corticostriatal dysfunction in bipolar disorder during emotional face processing.
Liu J, Blond BN, van Dyck LI, Spencer L, Wang F, Blumberg HP. Bipolar Disord. 2012 Jun;14(4):432-41.
Euthymia, depression, and mania: what do we know about the switch?
Blumberg HP. Biol Psychiatry. 2012 Apr 1;71(7):570-1.
- Stress reactivity and corticolimbic response to emotional faces in adolescents. Liu J, Chaplin TM, Wang F, Sinha R, Mayes LC, Blumberg HP. J Am Acad Child Adolesc Psychiatry. 2012 Mar;51(3):304-12.
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment.
Edmiston EE, Wang F, Mazure CM, Guiney J, Sinha R, Mayes LC, Blumberg HP. Arch Pediatr Adolesc Med. 2011 Dec;165(12):1069-77.
Structure-function associations in hippocampus in bipolar disorder.
Chepenik LG, Wang F, Spencer L, Spann M, Kalmar JH, Womer F, Kale Edmiston E, Pittman B, Blumberg HP. Biol Psychol. 2012 Apr;90(1):18-22.
The association of genetic variation in CACNA1C with structure and function of a frontotemporal system.
Wang F, McIntosh AM, He Y, Gelernter J, Blumberg HP. Bipolar Disord. 2011 Nov-Dec;13(7-8):696-700.
Lateral ventricle volume and psychotic features in adolescents and adults with bipolar disorder.
Edmiston EE, Wang F, Kalmar JH, Womer FY, Chepenik LG, Pittman B, Gueorguieva R, Hur E, Spencer L, Staib LH, Constable RT, Fulbright RK, Papademetris X, Blumberg HP. Psychiatry Res. 2011 Dec 30;194(3):400-2.