Graeme F Mason, PhD

Professor of Radiology and Biomedical Imaging and of Psychiatry; Director Metabolic Modeling and Director Psychiatric MRS; Director, Neuroimaging Sciences Training Program; Chair, Magnetic Resonance Research Center Protocol Review Committee

Departments & Organizations

Radiology & Biomedical Imaging: Bioimaging Sciences: Magnetic Resonance Research Center; Magnetic Resonance Spectroscopy | Collaborators | Neuroimaging Sciences Training Program

Psychiatry: Center for Nicotine and Tobacco Use Research at Yale (CENTURY) | Center for the Translational Neuroscience of Alcoholism | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Obsessive Compulsive Disorder Research Clinic

Diabetes Research Center

Faculty Research

Office of Cooperative Research

Biography

Dr. Grame F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry in conjunction with 13C isotopic labeling in vivo, in cell preparations, and other systems. His work began during his graduate studies at Yale where he used a rat model for the experimental determination of brain glucose transport kinetics, energetics, and neurotransmitter metabolism. Dr. Mason received further training at the University of Alabama at Birmingham, where he guided the group's 13C-labeling studies of the human brain in vivo in the 4.1T whole-body MR system. Dr. Mason currently studies metabolism and neurotransmission in the brain in vivo, including effects of psychiatric disorders and substances such as alcohol and nicotine; Dr. Mason examines healthy subjects and patients to investigate relationships among GABA, glutamate, and glutamine concentrations and their rates of synthesis and release in the brain, in particular with regard to effects of acute and chronic use of alcohol.

Education & Training

PhD Yale University (1991)
BS The Pennsylvania State University, Nuclear Engineering, Minor in Spanish (1986)
Postdoctoral Fellow University of Alabama at Birmingham, Center for Nuclear Imaging Research, Birmingham, AL
Postdoctoral Research Associate Yale University, New Haven, CT
Research Assistant Hershey Medical Center, Hershey, PA
Graduate Study Yale University, New Haven, CT

Honors & Recognition

  • Editor's Recognition for Reviewing, Biological Psychiatry (2016)

  • Elected FellowAmerican College of Neuropsychopharmacology (2015)

  • Elected Senior FellowInternational Society of Magnetic Resonance in Medicine (2015)

  • Editor's Recognition for Reviewing, Biological Psychiatry (2015)

  • Editor's Recognition for Reviewing, Biological Psychiatry (2014)

  • Editor's Recognition for ReviewingBiological Psychiatry (2012)

  • Editor's Recognition for Reviewing Biological Psychiatry (2011)

  • Editor's Recognition for ReviewingBiological Psychiatry (2009)

  • Editor’s Recognition Award for Reviewing with Special Distinction Radiology (2003), (2004)

  • NARSAD Young Investigator AwardNARSAD (2002), (2004)

  • Memorial Travel AwardAmerican College of Neuropsychopharmacology (2002)

  • NARSAD Young Investigator AwardNARSAD (2000), (2002)

  • Honorable Mention – alternate for Memorial Travel Award for American College of NeuropsychopharmacologyAmerican College of Neuropsychopharmacology (2000)

  • Stanley Foundation Young Investigator AwardStanley Foundation (1998), (2000)

  • Student Travel AwardsSociety of Magnetic Resonance in Medicine (1991), (1992)

  • NIH Graduate Fellowship National Institutes of Health (1986), (1991)

  • National Science Foundation Fellowship Honorable MentionNational Science Foundation (1986)

  • Institute of Nuclear Power Operations (INPO) ScholarshipInstitute of Nuclear Power Operations (1984), (1986)

  • John White Scholarship for Excellence in Spanish (1984), (1986)

Professional Service

  • Drug Abuse and Brain Imaging Training Program (DABITP), McLean Hospital, Boston, MA (2017 - Present) Scientific Advisory Board

  • American College of Neuropsychopharmacology, Education Committee (2016 - Present)

  • Alcohol: Clinical & Experimental Research (2016 - Present) Field Editor

  • Member, NPAS Study Section (2015 - 2016) Grant reviewer

  • Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2015 - Present) Journal Editorial Board

  • Alcohol Center, Medical University of South Carolina (2014 - Present) Scientific Advisory Board

  • Research Society on Alcoholism Education Committee (2014 - Present) Chair, Gordis Award Subcommittee

  • Psychiatric MR Study Group, in the International Society of Magnetic Resonance in Medicine (ISMRM) (2012 - 2015) Chair-Elect, then Chair, then Past Chair

  • Society of Biological Psychiatry (2011 - Present) Program Committee

  • Research Society on Alcoholism (2011 - Present) Education Committee

  • Research Society on Alcoholism (2008 - 2009) Research Priorities Committee

  • International Society of Magnetic Resonance in Medicine (2007 - 2008) Ad-Hoc Presidential Appointee to Study Group Review Committee

  • Research Society on Alcoholism (2006 - 2008) Program Committee

  • Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Association of America (2005 - 2009) Scientific Advisory Board

  • International Society of Magnetic Resonance in Medicine (ISMRM) (2005 - 2006) Past Chair of Psychiatric MR Study Group

  • Magnetic Resonance Research Center (2005 - Present) Protocol Review Committee

  • Yale Human Investigation Committee (2004 - Present) Advising on imaging-related protocols

  • National Institute of Complementary and Alternative Medicine (NCCAM) (2003 - 2009) Grant reviewer

  • National Institutes of Health (2003 - Present) Grant reviewer

  • International Society of Magnetic Resonance in Medicine (ISMRM) (2003 - 2005) Psychiatric MR Study Group

  • International Society of Magnetic Resonance in Medicine (2003 - 2005) Member of the Study Group Review Committee

  • Biological Psychiatry (2002 - Present) Journal Editorial Board

  • International Society of Magnetic Resonance in Medicine (ISMRM) (2001 - 2003) Conceived and organized Psychiatric Magnetic Resonance Study Group

  • Yale Human Investigation Committee (2000 - 2004) Protocol reviewer

Activities

  • Alcohol and Brain Metabolism Worcester, United States (2017 - 2017)

  • A metabolic perspective of alcohol dependence and withdrawal Delhi, India (2017 - 2017)

  • Effects of alcohol and nicotine on brain metabolism Boston, United States (2017 - 2017)

  • The first steps to getting your own money Berlin, Germany (2017 - 2017)

  • Grantcraft: The art of writing a successful grant proposal Berlin, Germany (2017 - 2017)

  • Basic NMR Theory Delhi, India (2017 - 2017)

  • 13C Studies of Metabolism In Vivo: Nuclear Magnetic Resonance (NMR) Spectroscopy and Mathematical Modeling Delhi, India (2017 - 2017)

  • Alcohol-Related Disorders: A Metabolic Perspective New York, United States (2016 - 2016)

  • Practical Aspects of 13C MR Studies Konstanz, Germany (2016 - 2016)

  • Relationships of Glutamate Concentrations with Glutamatergic Firing Atlanta, United States (2016 - 2016)

  • Principles of Metabolic Modeling of Isotopic Labeling Philadelphia, United States (2016 - 2016)

  • Magnetic Resonance Spectroscopy of Brain Metabolism of Glucose, Acetate, and Ethanol Athens, United States (2015 - 2015)

  • Neuroimaging of Effects of Ketamine São Paulo, Brazil (2015)

    Project with Renério Fraguas, Diretor da Divisão de Psiquiatria e Psicologia do Hospital Universitário - HU USP Coordenador do Grupo de Pesquisa em Depressão e Especialidades Médicas do Laboratório de Investigação Médica

  • 13C MRS Studies of Brain Metabolism of Alcohol and Acetate Birmingham, United States (2015 - 2015)

  • Brain Oxidation of Ethanol and Acetate: Influence of Chronic Alcohol Exposure Indianapolis, United States (2015)

  • Alcohol and Brain Metabolism Charleston, United States (2014)

  • Measurement of Heterogeneous Metabolism by 13C Magnetic Resonance Spectroscopy: Practicalities and Strategies Lexington, KY, United States (2014 - 2014)

  • Measurement of Heterogeneous Metabolism by 13C Magnetic Resonance Spectroscopy: Practicalities and Strategies Lexington, United States (2014)

  • Metabolic Kinetics in Psychiatric Disease Lisbon, Portugal (2013 - 2013)

  • MR Spectroscopy and Imaging for Beginners – parts 1 and 2 Lisbon, Portugal (2013 - 2013)

  • Dynamic Imaging and Spectroscopy of Psychiatric Illness Lisbon, Portugal (2013 - 2013)

    Chair, organizing committee for the ISMRM Workshop on Magnetic Resonance Imaging and Spectroscopy for Neuropsychiatric Disorders

  • Alcohol and the Brain: a Metabolic Perspective Orlando, Florida, United States (2013 - 2013)

  • Ethanol, its Metabolism, and the Brain Boston, Massachusetts, United States (2013 - 2013)

  • Espectroscopia por ressonância magnética: teoria e aplicação ao estudo dos efeitos cerebrais de étanol em dose aguda Rio de Janeiro, Brazil (2011)

  • Efeitos agudos de étanol no cérebro investigados pela técnica de espectroscopia de ressonância nuclear Porto Alegre, Brazil (2011)

  • Compartmental analysis and sensitivities of kinetic carbon-13 labeling studies Athens, Greece (2011)

  • Efeitos neuroquímicos do álcool e da nicotina observados in vivo com ressonância magnética Juiz de Fora, Brazil (2011)

    April 26, Juiz de Fora, Brazil

  • Efectos de Étanol en Neuroquímicos Cerebrales Buenos Aires, Argentina (2009 - 2009)

    Chair, Organizer of Symposium

  • Member Doctoral Thesis Evaluation Committee Lanzhou, China (2009)

    Member Doctoral Thesis Evaluation Committee

  • MRS Methodology for Studies of Alcoholism Paris, France (2008)

  • Neurotransmitters in Neuropsychiatric Disorders Quebec, Canada (2008 - 2008)

    Chair, organizing committee for the educational ISMRM Workshop on Magnetic Resonance Imaging and Spectroscopy for Neuropsychiatric Disorders

  • Espectroscopia por Ressonância Magnética Rio de Janeiro, Brazil (2008 - 2008)

    Co-chair of Educational Series at the Congresso IBRO/LARC de Neurociências da América Latina, Caribe, e Península Ibérica, Búzios, Brazil

  • Magnetic Resonance Spectroscopy in Neuropsychiatric Disorders Alberta, Canada; Banff, Canada (2005 - 2005)

    Chair, Organizing committee for the educational ISMRM Workshop on Magnetic Resonance Spectroscopy for Neuropsychiatric Disorders

  • Dynamic Measurements of Cortical GABA Kyoto, Japan (2004)

    Kyoto, Japan. Psychiatry Study Group of the International Society of Magnetic Resonance in Medicine

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