Behavior and Behavior Mechanisms; Psychiatry and Psychology
Pain and Pleasure are mediated by overlapping neurochemical pathways; however, little is known about how the brain mediates the perception of pain and pleasure using very similar brain circuitry and neurochemicals. The interaction of pain and pleasure in the brain is reflected in co-morbid conditions such as chronic pain and obesity. Hence, pathological pain and overeating (due to disruption in perception of food pleasure) are good clinical examples of how we can tackle this question. We use functional magnetic resonance imaging (fMRI) as well as psychophysical (pain and food pleasure perception) and neuro-hormonal measures to address these questions.
Extensive Research Description
Neural Mechanisms of Obesity in Chronic Low Back Pain
- Decreased food pleasure and disrupted satiety signals in chronic low back pain Pain 2014 Apr; 155(4): 712:22
- Smokers have differential brain response to food in regions that predict weight gain in non-smokers Am J Clin Nutr. 2013 Jan;97(1):15-22
- Predicting value of pain analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain Neuron. 2010 Apr 15; 66(1):149-60
- The brain in chronic CRPS pain: Abnormal gray-white matter interactions in emotional and autonomic regions Neuron. 2008 Nov 26; 60(4):570-81