Associate Research Scientist in Psychiatry
Meiyu has been a postdoc in the laboratory since 2009. Her focus has been studying the cellular and molecular mechanisms underlying the pathophysiology of Tourette syndrome (TS) using virus tools and mouse models. She received a grant award in 2011 from the Tourette Syndrome Association.
Meiyu's Ph.D. researches focused on the regulation of food intake and growth regulation by some endocrine hormones, e.g. prepro-orexin (OX), PACAP-related peptide, preprosomatostatin, etc.
Meiyu Xu, Lina Li, Hiroshi Ohtsu, Christopher Pittenger. Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show enhanced stereotypy following fear stress. Submitted to Neuroscience letters.
Meiyu Xu, Andrew Kobets, Jung-Chieh Du, Jessica B. Lennington, Lina Li, Mouna Banasr, Ronald S. Duman, Flora Vaccarino, Ralph DiLeone,.Christopher Pittenger, Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Submittted to PNAS
Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C. (2011) High levels of histidine decarboxylase in the striatum of mice and rats. Neurosci Lett. 495(2):110-4
Baldan Ramsey LC, Xu M, Wood N, Pittenger C. (2011) Lesions of the dorsomedial striatum disrupt prepulse inhibition. Neuroscience. 180:222-8.
Xu M., Volkoff H. (2009) Molecular characterization of ghrelin and gastrin-releasing peptide in Atlantic cod (Gadus morhua): Cloning, localization, developmental profile and role in food intake regulation. Gen Comp Endocrinol 160: 250–258
Xu M., Volkoff H. (2009) Cloning, tissue distribution and effects of food deprivation on pituitary adenylate cyclase activating polypeptide (PACAP)/PACAP-related peptide (PRP) and preprosomatostatin 1 (PPSS 1) in Atlantic cod (Gadus morhua). Peptides 30:766-76
Xu M., Volkoff H. (2007) Molecular characterization of prepro-orexin in Atlantic cod (Gadus morhua): Cloning, localization, developmental profile and role in food intake regulation. Mol Cell Endocrinol 271:28-37
Chen S., Xu M., Ji X., Yu G., Liu Y. (2005) Cloning, characterization, and expression analysis of hepicidin gene from red sea bream (Chrysophrys major). Antimicrob Agents Chemother 49:1608-12
Education & Training
- Ocean University of Qingdao (2002)
- Memorial University of Newfoundland (2009)