Marci Mitchell, PhD

Associate Research Scientist in Psychiatry

Research Summary

Dr. Mitchell is investigating the effects of sex and gender on impulsive choice behavior in addiction. She initially pursued this area of investigation in her doctoral work, using an animal model. Now she is bridging the gap between preclinical and clinical research to become an interdisciplinary investigator interested in translating findings into treatments and public health practice. Dr. Mitchell will use data from cocaine-dependent and healthy control subjects to determine whether there are gender differences in impulsive choice behavior and to determine if there are functional differences in how women and men process information in making choices. The purpose of this work is to understand the mechanisms of choice so interventions can be developed to affect those mechanisms for positive change.

Selected Publications

  • Mitchell, M.,R., Potenza, M.N., (2015). Importance of sex differences in impulse control and addictions. Frontiers Opinion Article. PMID: 25762943 PMCID: PMC4332159
  • Hamilton KR*, Mitchell MR*, Wing VC*, Balodis IM, Bickel W, Fillmore M, Lane SD, Lejuez CW, Littlefield AK, Luitjen M, Mathias C, Mitchell SH, Napier TC, Reynolds B, Schutz CG, Setlow B, Sher KJ, Swann A, Tedford SE, White MJ, Winstanley C, Potenza MN^, Moeller FG^ (2015). Choice impulsivity: definitions, measurement issues, and clinical implications. Personality Disorders: Theory, Research, and Treatment
  • Mitchell, M.R., Potenza, M.N. (2014). Recent insights into the neurobiology of impulsivity. Current Addiction Reports 1, 309-319. PMID: 25431750 PMCID: PMC4242429
  • Mitchell, M.R., Weiss, V.G., Ouimet, D.J., Morgan, D., Fuchs, R.A., & Setlow B. (2014). Intake dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. Behavioral Neuroscience 128(4), 419-429. PMCID: PMC4107092
  • Shimp, K.S., Mitchell, M.R., Beas, B.S., Bizon, J.L., & Setlow B. (2014). Affective and cognitive mechanisms of risky decision making. Neurobiology of Learning and Memory, S1074-7427(14), 00048-00043. PMCID: PMC4164592
  • Mitchell, M.R., & Potenza, M.N. (2014). Addictions and personality traits: impulsivity and related constructs. Current Behavioral Neuroscience Reports, 1(1), 1-12. PMID: 24772382 PMCID: PMC3996683
  • Mitchell M.R., Weiss, V.G., Beas, B.S., Morgan, D., Bizon, J.L., & Setlow, B. (2014). Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling. Neuropsychopharmacology.39(4), 955-962. PMID: 24145852 PMCID: PMC3924529
  • Mitchell, M.R., Balodis, I.M., DeVito, E.E., Lacadie, C.M., Yeston, J., Scheinost, D., Constable, R.T., Carroll, K.M., & Potenza, M.N. (2013). A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes. The American Journal of Drug and Alcohol Abuse 39(6), 392-402. PMCID: PMC3827911
  • Mitchell, M.R., Mendez, I.A., Vokes, C.M., Damborsky, J.C., Winzer-Serhan, U.H., & Setlow, B. (2012). Effects of developmental nicotine exposure on decision-making in adulthood. Behavioural Pharmacology 23(1), 34-42. PMCID: PMC3253892
  • Gilbert, R.J., Mitchell, M.R., Simon, N.W., Bañuelos, C., Setlow, B., & Bizon, J.L. (2011). Risk, reward, and decision-making in a rodent model of cognitive aging. Frontiers in Neuroscience 5(144), 1-10. PMCID: PMC3250056
  • Simon, N.W., Montgomery, K.S., Beas, B.S., Mitchell, M.R., LaSarge, C.L., Mendez, I.A., Bañuelos, C., Vokes, C.M., Taylor, A.B., Haberman, R.P., Bizon, J.L., & Setlow, B. (2011). Dopaminergic modulation of risky decision-making. J. Neuroscience 31(48), 17460-17470. PMCID: PMC3307370
  • Mitchell, M.R., Vokes, C.M., Blakenship, A.L., Simon, N.W., & Setlow, B. (2011). Acute administration nicotine, amphetamine, diazepam, morphine, and ethanol on risky decision-making in rats. Psychopharmacology 218(4), 703-712. PMCID: PMC3179555
  • Mendez, I.A., Simon, N.W., Hart, N., Mitchell, M.R., Nation, J.R., Wellman, P.J., & Setlow, B. (2010). Self-administered cocaine causes lasting increases in impulsive choice in a delay discounting task. Behavioral Neuroscience, 124(4), 470-477. PMCID: PMC2976632
  • Setlow, B., Mendez. I.A., Mitchell, M.R., & Simon, N.W. (2009). The effects of chronic administration of drugs of abuse on discounting of delayed rewards (impulsive choice) in animal models. Behavioural Pharmacology,(20), 380-389. PMCID: PMC2874684

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