Affective Disorders, Psychotic; Schizophrenia and Disorders with Psychotic Features
The main area of research interest has been investigating neurochemical underpinning of schizophrenia. More specifically, investigating effects and interactions of various psychoactive chemicals inducing clinical characteristics of schizophrenia or inducing vulnerability to psychosis in human subjects. In this context, I have involved in several challenge studies using ketamine, iomezanil, and amphetamine during my residency training at Seoul National University and postdoctoral fellowship at the VA-Yale schizophrenia research program. I also have some expertise in neuro-imaging studies from experience as a research fellow at Brain Imaging Center at McLean Hospital, Harvard Medical School. Currently, I am conducting study, as a PI, investigating interactive effects of GABA and Dopamine system in schizophrenia.
N-methyl-D-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory process.
N-methyl-D-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory process. Prog Neuropsychopharmacol Biol Psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):993-9.
White matter hyperintensities in subjects with bipolar disorder.
Ahn KH1, Lyoo IK, Lee HK, Song IC, Oh JS, Hwang J, Kwon J, Kim MJ, Kim M, Renshaw PF. White matter hyperintensities in subjects with bipolar disorder. Psychiatry Clin Neurosci. 2004 Oct;58(5):516-21. Psychiatry Clin Neurosci.
Probing GABA receptor function in schizophrenia with iomazenil.
Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine.
Full List of PubMed Publications
- Hamilton HK, D'Souza DC, Ford JM, Roach BJ, Kort NS, Ahn KH, Bhakta S, Ranganathan M, Mathalon DH: Interactive effects of an N-methyl-d-aspartate receptor antagonist and a nicotinic acetylcholine receptor agonist on mismatch negativity: Implications for schizophrenia. Schizophr Res. 2017 Jul 12; 2017 Jul 12. PMID: 28711472
- Ahn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC: Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine. Neuropsychopharmacology. 2015 Nov; 2015 May 8. PMID: 25953357
- Mathalon DH, Ahn KH, Perry EB Jr, Cho HS, Roach BJ, Blais RK, Bhakta S, Ranganathan M, Ford JM, D'Souza DC: Effects of nicotine on the neurophysiological and behavioral effects of ketamine in humans. Front Psychiatry. 2014; 2014 Jan 24. PMID: 24478731