Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders
Psychiatry: Center for the Translational Neuroscience of Alcoholism | Human Genetics, Division of | Molecular Psychiatry, Division of | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Psychotherapy Development Center | Stress & Addiction Clinical Research Program | VA Alcohol Research Center | VA-Yale Clinical Neurosciences PTSD Research Program
The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including cocaine, opioid, nicotine, and alcohol dependence, PTSD, panic and other anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.
The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include multicenter case/control association studies with the goal of identifying genes predisposing to cocaine, opioid, nicotine, and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; an international drug dependence genetics training project in collaboration with Chulalongkorn Faculty of Medicine (Bangkok, Thailand); studies of posttraumatic stress disorder (PTSD); and a VA study on the pharmacogenomics of antidepressant response. I also co-lead the Substance Use Disorders group of the Pschiatric Genomics Consortium.
Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Pharmacogenomics
- Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA. (2014) Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
- Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, and Gelernter J (2011) Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
- Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036.
- Wang Q, Yang C, Gelernter J, Zhao H. Hum Genet. Sep 4.
- Polimanti R, Yang C, Zhao H, Gelernter J. Pharmacogenomics. 2015 Aug;16(13):1487-98. doi: 10.2217/pgs.15.91. Epub 2015 Aug 12.
- Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. Mol Psychiatry. 2016 Apr 12. doi: 10.1038/mp.2016.43. [Epub ahead of print]
- Polimanti R, Kranzler HR, Gelernter J. Neuropsychopharmacology. 2016 Oct;41(11):2688-96. doi: 10.1038/npp.2016.72. Epub 2016 May 17.
- Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Biol Psychiatry. 2015 Mar 1;77(5):493-503. doi: 10.1016/j.biopsych.2014.08.025. Epub 2014 Sep 16