Golam M Chowdhury M.S. (Med), Ph.D.
Associate Research Scientist in Psychiatry
NMR; 13C NMR; in vivo and ex vivo brain metabolism; glutamate; gamma-aminobutyrate; glutamine; neuron-glial trafficking; depression; stress; brain development; drugs discovery; hypoxia; nanotoxicity; ketone bodies; ketamine; antidepressant; riluzole; SSADH
Glutamate and GABA are the major excitatory and inhibitory neurotransmitters in the central nervous system and together account for the majority of all of its neurons. Their synaptic actions are maintained through the process of complex metabolic cycles between neurons and neighboring astroglia. My research mainly focuses on deciphering the mechanism(s) linking glutamate and GABA neurotransmitter cycling to brain activity, and the role of glucose and alternative substrates (e.g., monocarboxylic acids) in this operation. My studies employ nuclear magnetic resonance (NMR) spectroscopy with stable isotope labeling (13C) and kinetic modeling to elucidate metabolic pathway fluxes in neurons and glia of the intact brain in vivo and ex vivo as well. In addition, I have determined the effects of chronic stress on the physiology and molecular biology of the amino acid neurotransmitter systems, especially targeting these systems for drug discovery and development. My other current research is concerned with understanding the role of altered glucose and neurotransmitter metabolism in rodent models of depression, diabetes, and epilepsy.
The major goals of these studies are following:
1. To understand the relationship between neurotransmission and neuroenergetics in the brain
2. To know the rates of glutamatergic and GABAergic neurotransmission
3. To know neuro-glial trafficking in the brain
4. Development of novel diagnostic strategies to improve treatment planning and prognosis of patients with mood and anxiety disorder
5. Exploring the role of cellular toxicity and neuroplasticity in the pathophysiology and treatment of mood disorders
6. To understand the mechanism of hypoxia and brain metabolism and metabolic adaptation
7. To understand the capacity of ketone bodies to replace glucose in support of neuronal function