Genotype; Magnetic Resonance Imaging; Neurobiology; Phenotype; Psychiatry; Psychotic Disorders; Substance-Related Disorders; Endophenotypes
Large-scale studies of individuals with major psychiatric disorders and their close relatives, and of healthy persons, combining genotyping results with biological measurements to determine risk of both neuropsychiatric disorders, and associations of normal behaviors and personality traits.
Specialized Terms: Endophenenotypes; multivariate genotype/phenotype relationships; psychosis; addiction; fMRI, DTI
Extensive Research Description
Large-scale, multi-disciplinary, multi-center, endophenotype-genotype investigations to study genetic determinants of pathologic conditions, including psychosis & alcoholism, as well as quantitative traits such as impulsivity and affective instability. Many of the data from these investigations are analyzed using multivariate statistical techniques such as parallel independent component analysis.
BSNIP:Bipolar Schizophrenia Network on Intermediate Phenotypes. A 3000-person study examining multiple endophenotypes in individuals with schizophrenia, psychotic bipolar disorder and schizoaffective disorder and their first-degree relatives that includes functional and structural imaging, EEG, cognitive and oculomotor testing and genotyping.
PARDIP:Psychosis and Related Domains- Intermediate Phenotypes. Similar to BSNIP, but conducted in non-psychotic bipolar patients and controls
BARCS:Brain and Alcohol Research in College Students. A longitudinal study that examines 2100 local college students for alcoholism risk and cannabis use using genotyping and multiple endophenotypes including EEG and structural/functional imaging over a 24-month period. This study includes regular Web-based reporting.of cannabis-impaired driving:
Neuroscience of cannabis-impaired vehicle driving: this NIDA-supported research examines the evolution over time of acute effects of various doses of smoked marijuana versus placebo on realistically simulated motor vehicle driving and various neurocognitive paradigms, both inside and outside the MRI scanner, along with biological measures of THC and metabolites inblood and saliva.
- Narayanan B, O'Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting state electroencephalogram oscillatory abnormalities in schizophrenia and psychotic bipolar patients and their relatives from the bipolar and schizophrenia network on intermediate phenotypes study. Biol Psychiatry. 2014 Sep 15;76(6):456-65. doi:10.1016/j.biopsych.2013.12.008. PubMed PMID: 24439302.
- Meda SA, Ruaño G, Windemuth A, O'Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Calhoun VD, Pearlson GD. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2066-75. doi: 10.1073/pnas.1313093111. Epub 2014 Apr 28. PubMed PMID: 24778245; PubMed Central PMCID: PMC4024891.