Gerard Sanacora PhD, MD

Professor of Psychiatry; Director, Yale Depression Research Program

Research Interests

Mood Disorders; Anxiety Disorders; Stress; Pathophysiology; Neuropharmacology; Neuroimaging; Drug Development; Magnetic Resonance Spectroscopy


Selected Publications

  • Laje, G., Lally, N., Mathews, D., Brutsche, Anat Chemerinski, A., Akula, N., Kelmendi, B., Simen, S., McMahon, F.J., Sanacora, G., Zarate, C. Brain-Derived Neurotrophic Factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients. Biological Psychiatry. In Press.
  • Abdallah, C.G., Fasula, M., Kelmendi, B., Sanacora, G., Ostroff, R. The Rapid Antidepressant Effect of Ketamine in the Electroconvulsive Therapy Setting. The Journal of ECT. In Press.
  • Chowdhury, G.M., Behar, K.L., Cho, W., Thomas, M.A., Rothman, D.L., Sanacora, G. (1)H-[(13)C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism. Biological Psychiatry. 2012 Jun 1;71(11):1022-1025.
  • Popoli, M., Yan, Z., McEwen, B.E., Sanacora, G, The Stressed Synapse: The Impact of Stress and Glucocorticoids on Glutamate Transmission, Nature Reviews Neuroscience, 2011 Nov 30;13(1):22-37.
  • Morgan PT, Pace-Schott EF, Mason GF, Forselius E, Fasula M, Valentine G.W, Sanacora G. Cortical GABA Levels in Primary Insomnia. Sleep. 2012 Jun 1;35(6):807-14.
  • Valentine, G., Mason, G.F., Gomez, R., Fasula, M., Watzl, J., Pittman, B., Krystal, J.H., Sanacora, G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [1H]-MRS. Psychiatry Research: Neuroimaging 2011 Feb 28;191(2):122-127.
  • Banasr, M., Chowdhury, G.M.I., Twillenger, R., Newton S., Duman, R.S., Behar K., Sanacora, G. Stress-induced glial pathology and depressive-behaviors are prevented by riluzole. Molecular Psychiatry. Mol Psychiatry. 2010 May;15(5):501-11.
  • Sanacora, G., Zarate, C. Krystal, J. Manji, H. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews Drug Discovery. 2008, 7(5):426-37

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