Evan Daniel Morris, PhD

Associate Professor of Diagnostic Radiology, of Biomedical Engineering and of Psychiatry; Co-director for Imaging, Yale PET Center

Research Interests

Research Organizations

Diagnostic Radiology: Bioimaging Sciences: Positron Emission Tomography

Interdepartmental Neuroscience Program

Psychiatry

Radiobiology & Radiotherapy

Extensive Research Description

Professor Morris specializes in using kinetic modeling to extract physiological information from dynamic PET images.

Morris and his group continue to refine mathematical and statistical aspects of their techniques for extracting transient neurotransmitter fluctuations induced by drugs or behaviors from dynamic PET data. The end-product of these modeling/image processing techniques are minute-by-minute "movies" of neurotransmitter release in the brain. Recent papers by Morris et al., (Neuroimage 2010) and Normandin et al (Neuroimage 2012) and Sullivan et al (AJNMMI 2013) and Kim et al (Hum Brain Map 2014) demonstrate the work. The culmination of these theoretical developments resulted in a paper by Cosgrove et al (J Neurosci 2014) showing differences in brain responses of male and female smokers while smoking.

Current projects include

a. relating occupancy of neuroreceptors by medications to medication efficacy
b. relating neurotransmitter dynamics to drug-seeking behavior
c. understanding medication efficacy through its effect on neurotransmitter dynamics
d. developing new models of temporal patterns in PET data as biomarkers of disease and risk
e. developing metrics for assessing the accuracy and precision of parametric images

Selected Publications

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Contact Info

Evan Daniel Morris, PhD
Office Location
Laboratory for Medicine and Pediatrics
15 York Street, Ste Suite 92 B

New Haven, CT 06510
Mailing Address
Diagnostic RadiologyPO Box 208042
Tompkin's East 2

New Haven, CT 06520-8042

Biomedical Engineering Dept

Morris homepage