Aryeh Herman PsyD
Associate Research Scientist in Psychiatry
Drug Addiction; Behavioral Genetics;Tobacco Use Disorder;Cognition;Pharmacogenetics
R03 DA027474-01 (Sofuoglu
and Herman) NIDA
- Sensitivity to Intravenous
Nicotine: Genetic Moderators
- This study will test the
influence of OPRM1 A118G status on subjective responses to IV nicotine, which
will be measured with the drug effects questionnaire (DEQ)
Nicotine is the main addictive substance in cigarettes. Researchers have yet to conclude whether nicotine has cognitive enhancing properties. My research is focused on investigating whether human genetics can help clarify whether nicotine can improve cognitive performance in both smokers and non-smokers. To answer this question, I bring smokers and non-smokers into our laboratory, collect their DNA, administer intravenous nicotine, and have them perform cognitive tasks while under the influence of nicotine. The goal of this research is to better understand individualized motivations for smoking as well as creating a pharmacogenetic model for cognitive enhancement.
- Sofuoglu, M., Herman, A.I., Mooney, M., Waters, A.J. (In Press). Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans. Psychopharmacology (Berl).
- Herman, A.I., Connor, T.S., Kranzler, H.R., Anton, R.F., Gelernter, J. Covault, J. (In Press). Variation in the Gene Encoding the Serotonin Transporter is Associated with a Measure of Sociopathy in Alcoholics. Addict Biol.
- Covault, J., Tennen, H., Armeli, S., Conner, T. S., Herman, A. I., Cillessen, A. H., et al. (2007). Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiatry, 61(5), 609-616.
- Herman, A. I., Kranzler, H. R., Cubells, J. F., Gelernter, J., & Covault, J. (2006). Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. Am J Med Genet B Neuropsychiatr Genet, 141B(5), 499-503.
- Herman, A. I., Kaiss, K. M., Ma, R., Philbeck, J. W., Hasan, A., Dasti, H., et al. (2005). Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women. Am J Med Genet B Neuropsychiatr Genet, 133B(1), 74-78.