Aryeh Herman, PsyD

Associate Research Scientist in Psychiatry

Research Interests

Impulse Control Disorders; Opioid-Related Disorders; Personality Disorders; Tobacco Use Disorder; Cocaine-Related Disorders; Alcohol-Related Disorders

Research Organizations

Addictions, Division of

Connecticut Mental Health Center

Research Summary

Nicotine is the main addictive substance in cigarettes. Researchers have yet to conclude whether nicotine has cognitive enhancing properties. My research is focused on investigating whether human genetics can help clarify whether nicotine can improve cognitive performance in both smokers and non-smokers. To answer this question, I bring smokers and non-smokers into our laboratory, collect their DNA, administer intravenous nicotine, and have them perform cognitive tasks while under the influence of nicotine. The goal of this research is to better understand individualized motivations for smoking as well as creating a pharmacogenetic model for cognitive enhancement.

Extensive Research Description

  • R03 DA027474-01 (Sofuoglu and Herman) NIDA
  • Sensitivity to Intravenous Nicotine: Genetic Moderators
  • This study will test the influence of OPRM1 A118G status on subjective responses to IV nicotine, which will be measured with the drug effects questionnaire (DEQ) Role: Co-Primary Investigator

Selected Publications

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