Alan S Lewis
animal models;aggression;substance use disorder;nicotine;nicotinic acetylcholine receptors;ion channels;schizophrenia;mood disorder
Chronic nicotine use remains a common problem for public health overall, and is a frequent comorbidity for patients with all types of substance use and psychiatric disorders. The overall goal of my research is to further understand the role of nicotinic cholinergic signaling in modulating behaviors of clinical relevance, especially impulsive aggression that can be observed in substance intoxication, withdrawal, and in neuropsychiatric conditions such as schizophrenia, bipolar spectrum disorder, neurocognitive, and neurodevelopmental disorders. Better understanding of novel mechanisms to regulate impulsive aggression might be amenable to translation into new therapeutics for people living with the above conditions.
- Lewis AS, Picciotto MR (2013) High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. Psychopharmacology (Berl) 229:477-485.
- Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM (2009) Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. Journal of Neuroscience 29:6250-6265.
- Lewis AS, Vaidya SP, Blais CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM (2011) Deletion of the HCN channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Journal of Neuroscience 31:7424-7440.
- Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM (2011) Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Journal of Biological Chemistry 286:20823-20834.
- Lewis AS, Chetkovich DM (2011) HCN channels in behavior and neurological disease: too hyper, or not active enough? Molecular and Cellular Neuroscience 46:357-67.