Alan Anticevic PhD
Assistant Professor of Psychiatry and of Psychology; Administrative Director, NIAAA Center for the Translational Neuroscience of Alcoholism
Schizophrenia; Psychotic disorders; Working memory; Emotion regulation; Substance abuse; Functional neuroimaging methods; Functional connectivity
Area 1: Pharmacological Neuroimaging & Computational Modeling
Area 2: Cognition-Emotion Interactions in Psychiatric Illness
Area 3: Functional Connectivity & Individual Differences in Psychiatric Illness
Extensive Research Description
Broadly, our group is interested in cognitive neuroscience of psychiatric illness. We seek to better understand, at the neural system level, the neural mechanisms behind cognitive and affective deficits in neuropsychiatric illness. Specifically, the research in our group focuses on understanding these processes in schizophrenia, bipolar illness and addiction. We use a combination of tools to better understand the neural systems involved in processing affective stimuli and their interaction with neural systems involved in goal-directed cognitive operations such as working memory. Methodologically, our lab harnesses the combination of task-based, resting-state, pharmacological functional neuroimaging, as well as computational modeling approaches to mechanistically understand neural circuit dysfunction in psychiatric disorders. Our experimental approaches depend on the combination of these tools to better understand the mechanistic links between neural circuit dysfunction and complex cognitive and affective processes and behaviors. The overarching objective of the lab is better understand the underlying neural circuit dysfunction in complex mental illness such as schizophrenia, with the aim of developing better neural markers and informing rationally-guided pharmacological treatments.
- Yang, J.G., Murray, J.D., Repovs, G., Cole, M.W., Savic, A., Glasser, M., Pittenger, C., Krystal, J.H., Wang, X-J. Pearlson, D.G., Glahn, D.C., Anticevic, A. (In Press). Altered global signal in schizophrenia. Proceedings of the National Academy of Sciences.
- Anticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M.W., Bednarski, S., Krystal, J.H., Bloch, M.B., Li, R.C-S., Pittenger, C. (2014). Global resting-state fMRI analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biological Psychiatry. 75(8):595-605.
- Cole, M.W., Repovs, G., & Anticevic, A. (In Press). The fronto-parietal control system: A central role in mental health. Neuroscientist.
- Anticevic, A., Savic, A., Repovs, G., Yang, G., McKay, D.R, Sprooten, E., Knowles, E., Krystal, J.H. Pearlson, G.D., Glahn, D.C. Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (In Press). Ventral anterior cingulate connectivity distinguished non-psychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophrenia Bulletin.
- Anticevic, A.*, Tang, Y.*, Cho, Y.T., Repovs, G., Cole, M.W., Savic, A., Wang, F., Krystal, J.H., & Xu, K. (2013) Amygdala connectivity at rest distinguishes between chronic, 1st episode and individuals at high risk for developing schizophrenia. *Denotes Equal Contribution. Schizophrenia Bulletin.
- Anticevic, A., Cole, M.W., Repovs, G., Savic, A., Driesen, N.R., Yang, G., Cho, Y.T., Murray, J.D., Glahn, D.C., Wang, X-J. and Krystal, J.H. (2013) Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Front. Psychiatry 4:169. doi: 10.3389/fpsyt.2013.00169
- Anticevic, A., Cole, M.W., Repovs, G., Murray J.D., Brumbaugh, M.S., Winkler, A.M., Savic, A., Krystal, J.H., Pearlson, G.D., & Glahn, D.C. (2013). Thalamo-cortical disturbances in schizophrenia and bipolar illness. Cerebral Cortex. (Email for reprint).
- Cole, M.W., Reynolds, J.R., Bassett, D., Power, J.D., Repovs, G., Anticevic, A., Braver, T.S. (In Press). Multi-task connectivity reveals flexible hubs for adaptive task control. Nature Neuroscience.
- Anticevic, A., Cole, M.W., Murray, J.D., Corlett, P.R., Wang, X-J., Krystal, J.H. (2012) The role of default network deactivation in cognition and disease. Trends in Cognitive Sciences. 16(12):584-92
- Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT and Krystal JH: Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Mol Psychiatry. 2013 Jan 22 Epub 2013 Jan 22. PMID: 23337947