Alan S Lewis
ion channels; microscopy; calcium signaling; nicotinic acetylcholine receptors; substance use disorders; dual diagnosis; schizophrenia; mood disorders
The goal of our research is to further understand the role of nicotinic acetylcholine receptors (nAChRs) in both normal cognition as well as in psychiatric and substance disorders. The properties and diversity of nAChRs make them well suited to modulate neural circuits that govern behaviors. My project is focused on understanding calcium signaling mechanisms downstream of nAChRs. Our goal is to identify the cells and brain regions in which these mechanisms are most relevant, and visualize the signal transduction events in vivo. Our ultimate goal is to understand how these signaling mechanisms may influence neuronal transmission properties within individual circuits.
- Lewis AS, Picciotto MR (2013) High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. Psychopharmacology. In press.
- Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM (2009) Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. Journal of Neuroscience 29:6250-6265.
- Lewis AS, Vaidya SP, Blais CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM (2011) Deletion of the HCN channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Journal of Neuroscience 31:7424-7440.
- Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM (2011) Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Journal of Biological Chemistry 286:20823-20834.
- Lewis AS, Chetkovich DM (2011) HCN channels in behavior and neurological disease: too hyper, or not active enough? Molecular and Cellular Neuroscience 46:357-67.