Alan S Lewis
biological psychiatry; nicotinic acetylcholine receptors; substance use disorders; dual diagnosis; schizophrenia; mood disorders
The goal of our research is to further understand the role of nicotinic acetylcholine receptors (nAChRs) in both normal cognition as well as in psychiatric and substance disorders. We use observations derived from patient data to direct our research questions. Specifically, we are currently trying to further define the mechanism underlying altered nAChR regulation in the brains of people with schizophrenia, with the goal of better understanding the mechanism of disease.
- Lewis AS, Picciotto MR (2013) High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. Psychopharmacology. In press.
- Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM (2009) Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. Journal of Neuroscience 29:6250-6265.
- Lewis AS, Vaidya SP, Blais CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM (2011) Deletion of the HCN channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Journal of Neuroscience 31:7424-7440.
- Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM (2011) Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Journal of Biological Chemistry 286:20823-20834.
- Lewis AS, Chetkovich DM (2011) HCN channels in behavior and neurological disease: too hyper, or not active enough? Molecular and Cellular Neuroscience 46:357-67.