Functional neuroimaging of alcoholism vulnerability: glutamate, reward, and Pavlovian-to-Instrumental Transfer
Principal Investigator: Dr. Godfrey Pearlson. This project will clarify the neurobiology of various forms of impulsivity and disordered reward mechanisms seen in individuals at risk for alcoholism. In particular it will use pharmacologic probes of the NMDA system to explore NMDA/DA interactions in the ventral striatum in a series of fMRI tasks related to reward to assess the relevant circuitry related to the above questions.
- Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. (2011). Individuals family history positive for alcoholism show functional magnetic resonance imaging differences in reward sensitivity that are related to impulsivity factors. Biol Psychiatry. 69(7):675-83. PMID: 21126735
- Meda SA, Stevens MC, Potenza MN, Pittman B, Gueorguieva R, Andrews MM, Thomas AD, Muska C, Hylton JL, Pearlson GD. (2009). Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis. Behav Pharmacol. 20(5-6):390-9. PMID: 19724194