The goal of the Genetics Core is to support the genetic components of each of the projects participating in this Center to help understand the nature of genetic influences on the phenotypes measured, and to allow for the ascertainment of genetic covariates that might affect those outcomes. We encourage that all subjects be asked to provide a DNA sample. Information on family history and other characteristics will be collected in the Clinical Core to provide the basis for analyses with DNA information.
Specific candidate genes have been identified as potentially important for each of the component projects in the center. We have the goal of sampling DNA from 100% of study subjects. The major function of the Genetics Core is to support genotyping for each of the projects (including pilot projects), for the purpose of identifying genotype/phenotype correlations.