John H. Krystal MD

Robert L. McNeil, Jr. Professor of Translational Research and Professor of Neurobiology; Chair, Department of Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD; Director, VA Alcohol Research Center; Medical Director, Schizophrenia Biological Research Center, DVA

Departments & Organizations

LCME Medical Students Subcommittee

DAHRSInterdepartmental Neuroscience ProgramNeurobiologyNIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders | Diabetes Research Center | Psychiatry: Center for the Translational Neuroscience of Alcoholism; Clinical Neuroscience Research Unit; Obsessive Compulsive Disorder Research Clinic; Adult Psychiatry; VA National Center for PTSD

Research Interests

Neurobiology; Pharmacotherapy; Genetics; Neuroimaging; Schizophrenia; Alcoholism; PTSD more...


  • B.A., University of Chicago, 1980
  • M.D., Yale University, 1984

Selected Publications

  • Krystal JH, Sanacora G, Duman RS. Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond. Biol Psychiatry. 2013 Jun 15;73(12):1133-41. doi: 10.1016/j.biopsych.2013.03.026. Review. PubMed PMID: 23726151; PubMed Central PMCID: PMC3671489.
  • Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proc Natl Acad Sci U S A. 2014 Dec 1. pii: 201413947. [Epub ahead of print] PubMed PMID: 25453062.
  • Wang XJ, Krystal JH. Computational Psychiatry. Neuron. 2014 Nov 5;84(3):638-654. doi: 10.1016/j.neuron.2014.10.018. Epub 2014 Nov 5. Review. PubMed PMID: 25442941; PubMed Central PMCID: PMC4255477.



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